SOLVED:The enzyme glycogen synthase kinase 3 β(GSK-3 β) plays a central role in Alzheimer's disease. The onset of Alzheimer's disease is accompanied by the production of highly phosphorylated forms of a protein referred to as " τ. " GSK-3 βcontributes to the hyperphosphorylation of τsuch that inhibiting the activity of this enzyme represents a pathway for the development of an Alzheimer's drug. A compound known as Ro 31-8220 is a competitive inhibitor of GSK-3 β. The following data were obtained