Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) [5] and phenylthiocarbamide (PTC).

Today we know that the ability to taste PTC (or not) is conveyed by a single gene that codes for a taste receptor on the tongue. The PTC gene, TAS2R38, was discovered in 2003. There are two common forms (or alleles) of the PTC gene, and at least five rare forms.

2024年12月25日 · TAS2R38 (Taste 2 Receptor Member 38) is a Protein Coding gene. Diseases associated with TAS2R38 include Thiourea Tasting and Dental Caries. Among its related pathways are GPCR downstream signalling and Sensory perception of taste.

2019年7月25日 · TAS2R38 is known as the bitter taste gene and it affects an individual’s response to taste bitter foods, with polymorphisms in the bitter taste receptor gene (TAS2R38) altering the ability to sense the intensity of bitterness of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).

2023年12月20日 · The Tas2r38 gene, also known as the “taste receptor 2 member 38”, is a gene that plays a crucial role in the sensation of bitter taste. It is primarily expressed in taste buds on the tongue and is responsible for detecting specific bitter compounds in our food and beverages.

2022年12月19日 · The bitter taste receptor gene TAS2R38 is a member of the human TAS2R gene family. Polymorphisms in TAS2R38 affect the ability to taste the bitterness of phenylthiourea (PTC) compounds, thus affecting an individual’s food preference and health status.

TAS2R38 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (summary by Conte et al., 2002). For further information on the TAS2R gene family, see 604791.

In this lab, we will study a gene that is associated with the taste of bitter compounds found in some of the foods we eat. Specifically, we will look at how the bitter taster phenotype compares to the genotype for the taste receptor gene TAS2R38.

[TAS2R38] This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been ...

Variations in TAS2R38 are associated with the ability to taste phenylthiocarbamide (PTC tasting) [MIM:171200]; also called thiourea tasting. The ability to taste the substance PTC and a number of related substances is genetically controlled.