2024年12月25日 · ZC3H18 (Zinc Finger CCCH-Type Containing 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is PPP1R10.

2019年10月11日 · We show that ZC3H18 is a DNA-binding protein that interacts with an E2F site in the BRCA1 promoter where it facilitates recruitment of E2F4 to an adjacent E2F site to promote BRCA1 transcription.

我们进一步证明 ZFC3H1 和 ZC3H18 的类似富含酸性的短线性基序竞争共同的 ARS2 表位。 因此，在促进 NEXT 功能的同时，ZC3H18 拮抗 PAXT 活性。 我们认为，RNA 衰变复合物的这种组织在基因座上提供了 NEXT 和 PAXT 的共同激活，并大量产生短外泌体底物。 The RNA exosome is a versatile ribonuclease.

The ZC3H18 protein binds the cap-binding complex (CBC), universally present on capped RNAs, while also associating with the nuclear exosome targeting (NEXT) complex, linking to RNA decay. To dissect ZC3H18 function, we conducted interaction screening and mutagenesis of the protein, which revealed a phosphorylation-dependent isoform.

2023年11月28日 · Here, mutational analysis of the core PAXT component ZFC3H1 uncovers a separate branch of the PAXT pathway, which targets short adenylated RNAs and relies on a direct ARS2-ZFC3H1 interaction. We further demonstrate that similar acidic-rich short linear motifs of ZFC3H1 and ZC3H18 compete for a common ARS2 epitope.

Gene ID: 124245, updated on 9-Feb-2025. Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in RNA destabilization. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Feb 2025]

2018年1月2日 · The ZC3H18 protein binds the cap-binding complex (CBC), universally present on capped RNAs, while also associating with the nuclear exosome targeting (NEXT) complex, linking to RNA decay. To...

2024年12月10日 · Title: ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. examination of ZC3H18 function, by genome-wide analyses, demonstrated its impact on transcription of a subset of protein-coding genes.

The ZC3H18 protein is involved in RNA decay mediated by the CBC-NEXT complex. Winczura et al. identify a phosphorylation-dependent interaction of ZC3H18 with histones, and they find separate CBCA-, NEXT-, and histone-binding domains. They suggest a role for ZC3H18 in mRNA biogenesis, which for some genes is independent of its role in RNA decay.

2019年10月11日 · Reduced BRCA1 expression causes homologous recombination (HR) repair defects in high-grade serous ovarian cancers (HGSOCs). Here, we demonstrate that BRCA1 is transcriptionally activated by a previously unknown function of ZC3H18. We show that ZC3H18 is a DNA-binding protein that interacts with an E …