ZO-1 makes critical, tight junction-independent contributions to Wnt signaling and mitotic spindle orientation. As a result, ZO-1 is essential for mucosal repair. We speculate that ZO-1 down-regulation may be one cause of ineffective mucosal healing in patients with IBD.

Jul 22, 2021 · Down-regulation of the tight junction protein ZO-1 in disease causes only mild increases in tight junction permeability but profoundly impairs mucosal healing.

ZO-1 was the first tight junction protein to be discovered. 22 It is a cytosolic peripheral membrane protein with multiple domains specialized for protein interactions. Among these are three PDZ (PSD95/Dlg/ZO-1) domains, a Src homology-3 (SH3) domain, …

Dec 25, 2024 · TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include Arrhythmogenic Right Ventricular Cardiomyopathy and Brain Edema. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Gene expression (Transcription).

Here, we demonstrate that the tight junction protein ZO-1 regulates tension acting on VE-cadherin–based adherens junctions, cell migration, and barrier formation of primary endothelial cells, as well as angiogenesis in vitro and in vivo.

The zonula occludens (ZO-1) protein-1 is a membrane-associated component of both tight junctions (TJ) and adherens junctions (AJ) found at the site of cell-cell contact.

May 23, 2024 · Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions...

ZO-1 has been demonstrated to interact with the transmembrane protein occludin, a second tight junction-specific MAGUK, ZO-2, and F-actin, although the nature and functional significance of these interactions is poorly understood.

Zonula occludens-1 (ZO-1) is a scaffolding protein of tight junctions, which seal adjacent epithelial cells, that is also expressed in adherens junctions. The distribution pattern of ZO-1 differs among stratified squamous epithelia, including that between skin and oral buccal mucosa.

Here, we provide a brief overview of ZO-1 and occludin canonical (barrier-related) functions, and a more detailed examination of their noncanonical functions. Keywords: actin; barrier; claudin; intestine; permeability.