ZEB2 is an R-SMAD-binding protein and acts as a transcriptional corepressor. It is involved in the timing of the conversion of neuroepithelial cells into radial glial cells in early development, a mechanism thought to allow for the large differences in …

2024年12月25日 · ZEB2 (Zinc Finger E-Box Binding Homeobox 2) is a Protein Coding gene. Diseases associated with ZEB2 include Mowat-Wilson Syndrome and Large Congenital Melanocytic Nevus. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

2024年1月25日 · Dai et al. report that the transcription factor ZEB2 is critical in driving ABC formation and pathogenicity in both mice and humans. ZEB2 promotes the gene signature, phenotype (e.g., CD11c expression), and function (e.g., phagocytic ability) of ABCs.

ZEB2, originally named SIP1 (and ZFHX1B), was discovered in a yeast 2-hybrid screening together with other candidate SMAD-interacting proteins (SIPs) from mid-gestation mouse embryos, using the transcription activation (i.e., MH2) domain of BMP-SMAD1 as bait [1].

2019年2月1日 · The two high ZEB2-expressing clones demonstrated robust increases in invasive capacity, as assessed by three types of invasion assay. These data identify ZEB2-mediated transcription as a key mechanism transforming the epithelial-like trophoblast into cells with a mesenchymal, invasive phenotype.

The ZEB2 gene provides instructions for making a protein that plays a critical role in the formation of many organs and tissues before birth. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.

Our goal was to overexpress ZEB2 in cultured trophoblast cell models to support or refute the hypothesis that the CTB to EVT transition is regulated by ZEB2, an EMT master regulatory transcription factor.

2025年2月3日 · ZEB2 is an autosomal dominant gene containing ten exons within the canonical version transcript (Isoform: O60315-1). The ZEB2 gene encodes six functional domains and seven non-domain regions.

Zinc finger E-box binding homeobox (Zeb) 2 is a transcription factor, identified due its ability to bind Smad proteins, and consists of multiple functional domains which interact with a variety of transcriptional co-effectors.

Zinc finger E-box–binding homeobox 2 (ZEB2) is a key developmental regulator of the central nervous system (CNS). Although the transcriptional regulation of ZEB2 is essential for CNS development, the elements that regulate ZEB2 expression have yet ...