
ZBP1 Gene - GeneCards | ZBP1 Protein | ZBP1 Antibody
2024年12月25日 · ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, …
ZBP1: A Powerful Innate Immune Sensor and Double-Edged …
2022年9月6日 · Z-conformation nucleic acid binding protein 1 (ZBP1), a powerful innate immune sensor, has been identified as the important signaling initiation factor in innate immune …
ZBP1: A Powerful Innate Immune Sensor and Double-Edged …
ZBP1 activated innate immunity, including type-I interferon (IFN-I) response and NF-κB signaling, constitutes an important line of defense against pathogenic infection. In addition, ZBP1 …
Decoding the multiple functions of ZBP1 in the mechanism of …
2024年10月21日 · Emerging evidence suggests an important role of Z-DNA binding protein 1 (ZBP1) as a sensor in innate immune to drive inflammatory signaling and cell death during …
ZBP1 condensate formation synergizes Z-NAs recognition and …
2024年7月9日 · Here, we show that ZBP1 condensate formation facilitates Z-NAs binding and antiviral signal transduction. The ZBP1 Zαβ dimerizes in a concentration-dependent manner, …
ZBP1 causes inflammation by inducing RIPK3-mediated ... - Nature
2024年6月7日 · Here we show that ZBP1 causes skin inflammation by inducing RIPK3-mediated necroptosis and RIPK1-caspase-8-mediated apoptosis in keratinocytes. ZBP1 induced TNFR1 …
ZBP1: Innate Sensor Regulating Cell Death and Inflammation
Here we review the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses. We also discuss the gaps in our knowledge …
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV
2025年3月7日 · Mitochondrial dysfunction can lead to liberation of mtDNA into the cytoplasm (27, 32, 33).After release of mtDNA, multiple pattern recognition receptors (PRRs), including …
ZBP1: Innate Sensor Regulating Cell Death and Inflammation
2017年11月24日 · Here we review the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses. We also discuss the gaps in our …
The Z-nucleic acid sensor ZBP1 in health and disease - PMC
ZBP1 is an innate immune sensor for double-stranded nucleic acids adopting the Z conformation. Z-RNA/DNA is generated during viral infections and in autoinflammation and cancer. By …
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