XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

2024年9月15日 · The latest motorsport images from Formula One, Formula Two, Formula Three, DTM, WRC and the World Endurance Championship.

核苷酸切除修复 （nucleotide excision repair, NER）是一种修复由紫外线和 化学致癌物 引起的各种DNA损伤的重要机制。 许多被 诊断 为着色性干皮病（xeroderma pigmentosum, XP）的患者在编码参与NER机制的蛋白的基因之一中存在突变。 众所周知，这些患者对紫外线引起的皮肤癌的高易感性是由于NER功能的缺乏。 这也告诉我们，NER是对癌症的一种防御。 NER的第一步涉及 XPC蛋白，它是多种XP致病性基因产物之一，它作为一种“传感蛋白”起作用，用于确定DNA结 …

2011年1月30日 · We report that triptolide covalently binds to human XPB (also known as ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the...

2015年3月1日 · XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter during the initiation of RNA polymerase II transcription; 2) to unwind double stranded DNA (dsDNA) around a DNA lesion during nucleotide excision repair ...

2012年5月10日 · Mutations in three subunits of TFIIH (XPB, XPD and p8) give rise to the autosomal recessive disorders xeroderma pigmentosum (which is sometimes associated with Cockayne syndrome) and...

Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition domain (DRD), a unique RED motif, a flexible thumb motif (ThM), and implied conformational changes within a conserved functional core.

2006年4月21日 · Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a component of transcription factor IIH, and proposed a mechanism for its dual role in transcription and nucleotide excision repair.

The XPB and XPD subunits each contain two RecA‐like domains (ATPase/helicase); XPB has 3′‐5′ helicase activity whereas XPD has 5′‐3′ helicase activity. XPB also possesses a DRD‐like (DNA Damage Recognition Domain) domain in addition …

XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter during the initiation of RNA polymerase II transcription; 2) to unwind double stranded DNA (dsDNA) around a DNA lesion during nucleotide excision repair ...