Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene. [5][6] The WNT gene family consists of structurally related genes that encode secreted signaling lipid modified glycoproteins.

2024年12月25日 · WNT5A (Wnt Family Member 5A) is a Protein Coding gene. Diseases associated with WNT5A include Robinow Syndrome, Autosomal Dominant 1 and Autosomal Dominant Robinow Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ncRNAs involved in Wnt signaling in hepatocellular …

WNT-5A, a prototypical WNT of β-catenin-independent branch, is highly conserved among species and plays key roles in the processes governing embryonic development, post-natal tissue homeostasis, and pathological disorders throughout the lifespan of an organism (Fig. 1) [4, 5].

Wnt5a is a representative ligand that activates the β-catenin-independent pathways. Because the β-catenin-independent pathway includes multiple signalling cascades in addition to the planar cell polarity and Ca(2+) pathway, Wnt5a regulates a variety of …

WNT5A is a putative epi-driver of prostate cancer metastasis to the bone. Differential expression of WNT5A long and short isoforms in non-muscle-invasive bladder urothelial carcinoma. Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma.

The WNT5A gene is part of a large family of WNT genes, which play critical roles in development starting before birth. Learn about this gene and related health conditions.

2025年2月8日 · Title: WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway. Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil.

Wnt5a signaling is critical for regulating normal developmental processes, including stem cell self-renewal, proliferation, differentiation, migration, adhesion, and polarity.

Wnt5a, a secreted glycoprotein, belongs to the noncanonical Wnt family involved in a wide range of organism development and tissue homeostasis. Wnt5a and its signaling pathway can regulate fundamental cellular processes, including specification of cell fate, proliferation, and survival.

Clinical resource with information about WNT5A, Autosomal dominant Robinow syndrome 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation.

Wnt5a, a secreted glycoprotein, belongs to a family of highly conserved proteins that regulate important processes such as cell fate specification, embryonic development, cell proliferation, migration, and differentiation in a variety of organisms.

2019年5月9日 · Wnt5a is a signalling protein mainly involved in developmental processes and cancer. The effect of Wnt5a on inflammatory myeloid cells is controversial. Here, we combine primary cell cultures,...

2023年12月1日 · Wnt5a is a highly evolutionarily conserved non-canonical Wnt ligand on chromosome 3p14-p21 and contains multiple polyadenylation sites. Wnt5a can activate both canonical and non-canonical signaling pathways, and different signaling pathways lead to Wnt5a playing different roles in different diseases [7], [8]. Recent studies have shown that ...

2024年5月15日 · WNT5A was identified as a predominant noncanonical WNT ligand in fibrotic diseases such as systemic sclerosis, sclerodermatous chronic graft-versus-host disease, and idiopathic pulmonary fibrosis, stimulating fibroblast-to-myofibroblast transition and tissue fibrosis by activation of latent TGF-β.

2011年3月29日 · Wnt5a is a representative ligand that activates the β-catenin-independent pathways. Because the β-catenin-independent pathway includes multiple signalling cascades in addition to the planar cell polarity and Ca 2+ pathway, Wnt5a regulates a variety of cellular functions, such as proliferation, differentiation, migration, adhesion and polarity.

2013年11月18日 · The mechanism by which WNT5A achieves these distinct activities in cancers is poorly understood. Here, we provide evidence that the WNT5A gene produces two protein isoforms, WNT5A-long (WNT5A-L) and WNT5A-short (WNT5A-S).

Actually, macrophage-derived Wnt5a maintains macrophage immune function, stimulates pro-inflammatory cytokine release, and induces angiogenesis and lymphangiogenesis. Furthermore, macrophage-derived Wnt5a is involved in insulin resistance, atherosclerosis and cancer.

These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the …

This review focuses on a thorough characterization of the role of WNT5A in neoplastic transformation and progression, which may help to understand the prognostic potentiality of WNT5A and its features as a therapeutic target in several cancers.