Wee1 - Wikipedia
Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key …
WEE1 Gene - GeneCards | WEE1 Protein | WEE1 Antibody
Dec 25, 2024 · WEE1 (WEE1 G2 Checkpoint Kinase) is a Protein Coding gene. Diseases associated with WEE1 include Breast Cancer and Ciliary Dyskinesia, Primary, 20. Among its …
Wee1 Kinase: A Potential Target to Overcome Tumor Resistance …
Wee1 is the principal gatekeeper for both G2/M and S-phase checkpoints, where it plays a key role in cell cycle regulation and DNA damage repair.
Comprehensive multi-omics analysis reveals WEE1 as a ... - Nature
Mar 7, 2024 · Based on the phospho-signature, we pinpoint CDK1 kinase is hyperactivated during hyperthermia, influencing the global signaling landscape. We observe dynamic, reversible …
A WEE1 family business: regulation of mitosis, cancer progression, …
Sep 21, 2020 · This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus …
Wee1 kinase as a target for cancer therapy - PubMed
Oct 1, 2013 · Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the …
SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 …
Jan 12, 2023 · The deacetylase SIRT1 directly associates with and modifies WEE1 to inactivate it enabling resistance to WEE1 inhibition in cancer cells.
WEE1 Tyrosine Kinase, A Novel Epigenetic Modifier - PMC
The WEE1 kinase was identified as an important regulator during S phase, preventing entry into mitosis until DNA replication has been completed. Interestingly, WEE1 has also emerged as a …
Cell cycle involvement in cancer therapy; WEE1 kinase, a potential ...
Jan 1, 2022 · Therefore, inhibition of WEE1 kinase could sensitize cancer cells to chemotherapeutic drugs. This review focuses on the role of WEE1 kinase (as a biological …
A novel WEE1 pathway for replication stress responses
Feb 11, 2021 · It is well known that the evolutionarily conserved protein kinase WEE1 regulates replication stress responses by directly phosphorylating and inhibiting the major cell cycle …
Wee1 - an overview | ScienceDirect Topics
Wee1 is a tyrosine kinase that is known to be overexpressed in many cancer types such as luminal and HER2-positive breast cancer subtypes, hepatocellular carcinomas, and …
The expanding role of WEE1 - ScienceDirect
Jun 1, 2022 · The expanding role of WEE1 in pathophysiology is matched by the keen surge of interest in developing WEE1-targeted therapeutic agents. This review summarises WEE1 …
WEE1 kinase limits CDK activities to safeguard DNA replication …
Here, we review how WEE1 regulates cell-cycle progression highlighting the importance of this kinase for proper S phase. We discuss how its function is modulated throughout different cell …
A WEE1 family business: regulation of mitosis, cancer ... - PubMed
Sep 21, 2020 · This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus …
Structural conservation of WEE1 and its role in cell cycle
Dec 13, 2021 · In this in silico study, we assessed the structural conservation of the WEE1 protein in the plant kingdom with a particular focus on agronomically valuable plants, the legume crops.
WEE1 inhibition induces anti-tumor immunity by activating …
Nov 26, 2021 · WEE1 inhibition increases endogenous retroviral elements (ERVs) expression by relieving SETDB1/H3K9me3 repression through down-regulating FOXM1. ERVs trigger …
Wee1 promotes cell proliferation and imatinib resistance in …
Dec 27, 2022 · Wee1 is extensively involved in the DRR signaling and DSB repair pathway. Inhibiting abnormally elevated Wee1 benefits CML therapy in both IM-resistant and IM …
The expanding role of WEE1 - PubMed
The expanding role of WEE1 in pathophysiology is matched by the keen surge of interest in developing WEE1-targeted therapeutic agents. This review summarises WEE1 involvement in …
Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer
Aug 14, 2017 · Wee1 is a protein kinase that regulates the G 2 checkpoint and prevents entry into mitosis in response to DNA damage (Fig. 1; ref. 1). The cell cycle is a highly controlled …
Targeting WEE1 Kinase in Cancer - Cell Press
Jul 14, 2016 · WEE1 is highly expressed and active in several cancer types that depend on a functional G2–M checkpoint for DNA repair. Targeting WEE1 for inhibition and compromising …