Wee1 Kinase: A Potential Target to Overcome Tumor Resistance …
Wee1 is the principal gatekeeper for both G2/M and S-phase checkpoints, where it plays a key role in cell cycle regulation and DNA damage repair.
WEE1 Gene - GeneCards | WEE1 Protein | WEE1 Antibody
2024年12月25日 · WEE1 (WEE1 G2 Checkpoint Kinase) is a Protein Coding gene. Diseases associated with WEE1 include Breast Cancer and Ciliary Dyskinesia, Primary, 20. Among its …
Comprehensive multi-omics analysis reveals WEE1 as a ... - Nature
2024年3月7日 · Based on the phospho-signature, we pinpoint CDK1 kinase is hyperactivated during hyperthermia, influencing the global signaling landscape. We observe dynamic, …
WEE1 Inhibitor: Clinical Development - PMC - PubMed Central …
WEE1 kinase is a serine-threonine kinase that regulates G2/M checkpoint transition [1–3]. WEE1 triggers G2/M arrest through inhibitory phosphorylation on Tyr15 of CDK1 (Cdc2) and …
Wee1 kinase as a target for cancer therapy - PubMed
2013年10月1日 · Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the …
A WEE1 family business: regulation of mitosis, cancer progression, …
2020年9月21日 · This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with …
WEE1 Tyrosine Kinase, A Novel Epigenetic Modifier - PMC
The WEE1 kinase was identified as an important regulator during S phase, preventing entry into mitosis until DNA replication has been completed. Interestingly, WEE1 has also emerged as a …
Cell cycle involvement in cancer therapy; WEE1 kinase, a potential ...
2022年1月1日 · Therefore, inhibition of WEE1 kinase could sensitize cancer cells to chemotherapeutic drugs. This review focuses on the role of WEE1 kinase (as a biological …
Structural conservation of WEE1 and its role in cell cycle
2021年12月13日 · In this in silico study, we assessed the structural conservation of the WEE1 protein in the plant kingdom with a particular focus on agronomically valuable plants, the …
The expanding role of WEE1 - ScienceDirect
2022年6月1日 · The expanding role of WEE1 in pathophysiology is matched by the keen surge of interest in developing WEE1-targeted therapeutic agents. This review summarises WEE1 …
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