2017年11月27日 · Vps34 inhibition alters cellular energy metabolism, activating the AMPK pathway in liver and muscle. In liver, Vps34 inactivation mildly dampens autophagy, limiting substrate availability for...

2023年8月5日 · VPS34 is involved in regulating epidermal growth factor receptor (EGFR) nuclear translocation, which in turn promotes AKT/HK2 (protein kinase B/hexokinase Ⅱ)-regulated glycolysis. Simultaneous inhibition of autophagy and glycolysis by VPS34 results in a significant increase in the sensitivity of Osimertinib resistant cells to Osimertinib [33].

2021年3月10日 · These findings reveal how VPS34 complexes are activated on membranes by specific Rab GTPases and how they are recruited to unique cellular locations.

One family member, Vps34, is of particular interest because it is the only PI3-kinase identified in yeast and it has been evolutionarily conserved through mammals. Vps34 plays an essential role in the cellular process of autophagy, a process linked to human health and disease.

Recent studies on the activation mechanisms of VPS34/Vps34 complexes have revealed that a variety of factors, including conformational changes, lipid physicochemical parameters, upstream regulators, and downstream effectors, greatly influence the activity of these complexes.

2017年9月21日 · Here, we report that VPS34 is specifically acetylated by the acetyltransferase p300, and p300-mediated acetylation represses VPS34 activity. Acetylation at K771 directly diminishes the affinity of VPS34 for its substrate PI, while acetylation at K29 hinders the VPS34-Beclin 1 core complex formation.

2023年6月2日 · Vps34 is a catalytic subunit of the class III PI3K complex, which phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PtdIns(3)P], promoting autophagy and endolysosomal trafficking.

2017年7月17日 · Vacuolar protein sorting 34 (Vps34) is a class III PI3K that plays a role in endocytosis, intracellular vesicular trafficking, and autophagosome formation during autophagy (10).

2014年10月19日 · A small-molecule inhibitor of the type III phosphatidylinositol 3-kinase, Vps34, binds the ATP binding pocket and prevents vesicle trafficking and autophagy.

2023年8月5日 · VPS34 is well-known to be the unique member of the class III phosphoinositide 3-kinase (PI3K) family, forming VPS34 complex 1 and complex 2, which are involved in several key physiological processes.