We found an increased number of VGF-expressing T cells in patients with AD compared to aged healthy controls, which was associated with enhanced HbA1c levels in blood. Upon treatment with rivastigmine, T cell proliferation and VGF expression in AD patients decreased to …

In this review, we summarize recent studies that identify the physiological roles of VGF and VGF-derived peptides, their dysregulation in and potential use as neurodegenerative and psychiatric disease biomarkers and novel therapeutic targets.

2020年4月14日 · Secretion of VGF is increased in cerebrospinal fluid and blood in neurodegenerative disorders like Alzheimer’s disease (AD) and VGF is a potential biomarker for these disorders. We investigated if VGF is expressed in T-lymphocytes and if this correlates to pharmacological treatment in AD.

2021年7月8日 · Our results therefore reveal a rapid, transcription-independent induction of VGF and other granin proteins after learning that are triggered by the VGF-derived peptide TLQP-62.

We found an age-dependent increase in the number of VGF+CD3+ T cells that correlated with HbA1c and the body mass index (BMI). VGF-expression by NK cells was age-independent. Blockade of VGF reduced proliferation and secretion of cytokines such as IL-2, IL-17A, IL-1β, IL-10 and TNF by CD3+ T cells and PBMCs.

VGF induces proliferation and cytokine production by T cells and PBMCs. Isolated T cells were stimulated with aCD3/28 or PMA/Ionomycin (as positive control) or were left untreated (medium...

In the present study, we found that contextual fear training induced a rapid increase in the levels of VGF and other granin proteins in the dorsal hippocampus without measurable changes in the...

3 天之前 · VGF and VGF-derived AQEE30 peptide from MK-CM stimulate bone formation in vitro. To identify a novel bone-forming factor from MK-CM, we used a fractionated secretome strategy.

2015年6月20日 · We have shown that VGF is expressed in peripheral T cells and is correlated with T cell survival and cytokine secretion. The frequency of VGF+CD3+ T cells increases with normal aging.

Both the mRNA and encoded approximately 68-kDa protein (VGF) are selectively synthesized in neuroendocrine and neuronal cells. The predicted VGF sequence is rich in paired basic amino acid residues that are potential sites for proteolytic processing, and VGF undergoes regulated release from dense core secretory vesicles.