VGF and VGF-derived peptides have been repeatedly identified in well-powered and well-designed multi-omic studies as dysregulated in neurodegenerative and psychiatric diseases. New therapeutics is urgently needed for these devastating and costly diseases, as are new biomarkers to improve disease diagnosis and mechanistic understanding.

Jul 1, 2022 · These studies revealed a novel active neuroendocrine regulatory polypeptide, VGF nerve growth factor inducible (VGF). VGF is an NGF-inducible transcript in PC12 cells, and this non-acronymic name is accepted because the identified clone was selected from plate “V” of a PC12 cDNA library [7].

Mar 13, 2025 · We revealed that Vgf, a nerve growth factor-responsive gene, and its derived active peptide AQEE30 in MK-conditioned medium play important roles in osteoblast proliferation and in vitro bone...

Feb 1, 2015 · The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain-derived neurotrophic factor, and glial-derived growth factor. The VGF gene gives rise to a 68 kDa precursor polypeptide, which is induced robustly, relatively selectively ...

从参与阿尔茨海默病发病机制的 537 个基因列表中，vgf 被阿尔茨海默病加速药物合作伙伴关系强调为最受关注的潜在治疗靶点。与对照组相比，阿尔茨海默病患者的脑组织和脑脊液样本中 vgf 水平持续降低，其水平与疾病严重程度和阿尔茨海默病病理学相关。

In this study, we investigated the VGF mRNA distribution in human spinal cord by in situ hybridization because VGF is a secreted protein. Subsequently, in situ hybridization and immunostaining performed simultaneously in VGF mRNA located area to investigate the cell types which produce VGF and expression change of VGF in ALS patients. Lastly ...

VGF (nonacronymic) is a granin-like neuropeptide precursor whose expression is robustly regulated by neuronal lesions and growth factors. 9, 34, 55 VGF-derived peptides have a functional role in several disorders including obesity, dementia, depression, and pain. This review focuses on the role of VGF in pain pathways.

Oct 27, 2021 · VGF and VGF-derived peptides have been repeatedly identified in well-powered and well-designed multi-omic studies as dysregulated in neurodegenerative and psychiatric diseases. New therapeutics is urgently needed for these devastating and costly diseases, as are new biomarkers to improve disease diagnosis and mechanistic understanding.

Jul 8, 2021 · Here, we show that either contextual fear memory training or the administration of TLQP-62, a peptide derived from the C-terminal region of the VGF precursor, acutely increases the translation of...

Jan 10, 2020 · VGF-derived peptide TLQP-21 activates the complement C3a receptor-1 (C3aR1), predominantly expressed in the brain on microglia. However, it is unclear how mouse or human TLQP-21, which are not identical, modulate microglial function and/or AD progression.