Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. [5] The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation.

Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple domains characteristic of signal transducing proteins, including a Dbl homology domain, a hallmark of a guanine nucleot …

2024年12月25日 · VAV1 (Vav Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with VAV1 include Immunodeficiency 62 and Dyskeratosis Congenita, Autosomal Dominant 6. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and p75 NTR receptor-mediated signalling.

2024年7月25日 · The guanine nucleotide exchange factor (GEF) VAV1, a previously ‘undruggable’ protein integral to T/B lymphocyte antigen–receptor signaling, promotes actin polymerization, immunological synapse formation, T cell activation and differentiation, and cytokine production.

Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.

Vavl, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T cell receptor (TCR) signaling cascade, is rapidly tyrosine phosphorylated in response to T cell activation. Vav1 has established roles in proliferation, cytokine ...

The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to microclusters and to the IS in primary CD4 + and CD8 + T cells.