In graft vs. host disease (GvHD), the donated stem cells you receive during an allogeneic stem cell transplant view your body’s cells as a threat and attack. There are two main types of GvHD: acute GvHD and chronic GvHD. Treatments include drugs that suppress (calm) your immune system. What is graft vs. host disease (GvHD)?

2024年6月7日 · Graft-versus-host disease (GVHD) is a systemic disorder occurring when immune cells from transplanted tissue recognize the recipient's body as foreign and attack its cells. In this context, graft refers to transplanted or donated tissue, while host refers to the recipient's tissues.

GVHD consists of inflammation induced by the conditioning regimen, the alloimmune response of the T lymphocytes, and organ damage due to the graft- vs -host reaction. Biological factors have been comprehensively analyzed to identify novel combinations of biomarkers that predict acute GVHD severity and prognosis more efficiently.

With ongoing monitoring and a multidisciplinary team of experts who know how to manage this disorder, the problems linked to GVHD may improve and even go away. The sooner treatment begins, the better your outcome will be. Most people are in treatment for 2 to 3 years, but some people require longer treatments. For GVHD, you may receive:

Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, et al. Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells. Blood (2016) 128:2568–79. doi: 10.1182/blood-2016-07-726547 [PMC free article] [Google Scholar] 72.

2023年6月8日 · Acute graft-versus-host disease (GVHD) is a common immune complication that can occur after allogeneic haematopoietic cell transplantation (alloHCT). Acute...

2021年12月10日 · Chronic graft-versus-host disease (GVHD) is the leading cause of late morbidity and mortality after allogeneic hematopoietic cell transplantation. Symptoms and manifestations of chronic GVHD are heterogeneous and pleomorphic, and there are no standard treatments beyond corticosteroids.

Graft-versus-host disease (GVHD) occurs when alloreactive T cells from the donor attack healthy tissues in the recipient and arises almost exclusively in patients who have undergone allogeneic HSCT 3.

2024年4月11日 · Acute graft-versus-host disease (GvHD) remains a major course of short term (100 days and 1 yr) mortality and morbidity after allogeneic stem cell transplantation.

Find information on graft-versus-host disease (GVHD), including the types, managing GVHD, your transplant journey, community support, and resources.