Dec 25, 2024 · UQCC3 (Ubiquinol-Cytochrome C Reductase Complex Assembly Factor 3) is a Protein Coding gene. Diseases associated with UQCC3 include Mitochondrial Complex Iii Deficiency, Nuclear Type 9 and Isolated Complex Iii Deficiency. Among its related pathways are Respiratory electron transport and Complex III assembly.

Jul 29, 2024 · These data suggest that PARL is crucial for nuclear localization of UQCC3 under hypoxia, highlighting the importance of amino acids 26–29 in PARL-mediated mitochondrial cleavage of UQCC3.

Jul 13, 2023 · Knockout of UQCC3 resulted in slower tumor growth and angiogenesis. Mechanistically, UQCC3 was upregulated under hypoxia, promoted reactive oxygen species (ROS) generation, enhanced HIF-1α stability and increased VEGF expression.

Feb 8, 2025 · Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma. AY358935 gene has an anti-VSV effect, and its anti-virus mechanism may involve the interferon-associated natural immune response.

Nov 3, 2020 · UQCC3 expression is required by HIF-1α stabilization in hypoxia and thus is important for ATP production from glycolysis. Collectively, UQCC3 is indispensable for bioenergetic reprogramming by orchestrating OXPHOS and glycolysis in hypoxic HCC cells.

Aug 3, 2023 · Here, we investigated the function of UQCC3 in angiogenesis in multiple Uqcc3-deficient animal models, including a TALEN-mediated knockout mouse, CRISPR/Cas9-mediated knockout zebrafish, and a liver-specific conditional (Cre …

Mar 5, 2024 · Clinical resource with information about UQCC3, Mitochondrial complex III deficiency nuclear type 9, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Jul 29, 2024 · Hypoxia-induced nuclear localization of ubiquinol-cytochrome-c reductase complex assembly factor 3 (UQCC3) in hepatocellular carcinoma Signal Transduct Target Ther . 2024 Jul 29;9(1):191. doi: 10.1038/s41392-024-01909-x.

Nov 3, 2020 · UQCC3 forms a positive feedback loop with mitochondrial ROS to sustain mitochondrial homeostasis, HIF-1α stabilization, and glycolytic activity in hypoxia and thus promotes bioenergetic reprogramming of HCC cells by …

Dec 1, 2014 · Complex III is a mitochondrial inner membrane protein aggregate that transfers electrons from ubiquinol to cytochrome c. UQCC3 is an assembly factor required for efficient complex III assembly (Wanschers et al., 2014).