USP9X is a protein-coding gene that has been implicated either directly through mutations or indirectly in a number of neurodevelopmental and neurodegenerative disorders. Three mutations have been connected with X-linked intellectual disability …

Dec 25, 2024 · USP9X (Ubiquitin Specific Peptidase 9 X-Linked) is a Protein Coding gene. Diseases associated with USP9X include Intellectual Developmental Disorder, X-Linked 99, Syndromic, Female-Restricted and Intellectual Developmental Disorder, X-Linked 99 .

The X-linked deubiquitinase USP9X has been implicated in multiple pathological disorders including malignancies and X-linked intellectual disability. However, its biological function and substrate repertoire remain to be investigated. In this study, ...

USP9X promotes the deubiquitination and stabilization of diverse substrates, thereby exerting a versatile range of effects on pathological and physiological processes. USP9X serves vital roles in the processes of cell survival, invasion and migration in various types of cancer.

Mar 31, 2017 · We demonstrate that USP9X is an integral component of centrosome and is required for centrosome biogenesis. Loss-of-function of USP9X impairs centrosome duplication and gain-of-function of...

Previously, as part of a large systematic resequencing of the X chromosome in 208 unrelated families with nonsyndromic X-linked intellectual disability, we identified three unique variants (two missense and one protein truncating) in USP9X.

USP9X is a key deubiquitinase for ALDH1A3 protein stabilization and a potential target for glioblastoma stem cell-directed therapy; show that USP9X-mediated BCL9 deubiquitination promotes the proliferation and invasion of breast cancer cells; USP9X promotes tumorigenesis and FBXW11 suppresses tumorigenesis through PTENalpha/beta.

Mar 25, 2021 · Usp9x is a marker of “stemness” and is mutated in various neurological disorders and cancers. Our results unveil a Usp9x-PRC2 regulatory axis that is critical at peri-implantation and may be...

Lei et al. demonstrate that USP9X is a key deubiquitinase controlling Wnt signaling by stabilizing β-catenin in the central nervous system (CNS) vasculature. Loss of USP9X in CNS endothelial cells impairs CNS angiogenesis and barrier function under …

May 1, 2024 · In this review, we provide a comprehensive delineation of USP9X participation in numerous critical cellular processes, complicated signaling pathways within the tumor microenvironment, and its potential translational applications to combat therapeutic resistance.