Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene. [5] [6]Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar isoforms of an enzyme that in humans is encoded by the ULK1/2 genes. [7] [8] The enzyme is specifically a kinase that is involved with autophagy, particularly in response to amino acid withdrawal.

ulk1 复合物在体内是连接上游营养或能量感受器 mtor 和 ampk 与下游自噬体形成的桥梁。磷酸化的 ulk1 一直以来都被认为是自噬的一个关键调控因子，目前发现 ampk 和 mtor 这两个激酶可催化 ulk1 的磷酸化，这在自噬中起着十分重要的作用。 ...

May 23, 2024 · ulk1 和 ulk2 高度受多个磷酸化位点调控。 6 激活时，ulk1 复合体与吞噬泡结合，从而在吞噬泡膜上形成 ulk1 小点，在这里数个其他复合体随后以一个仍知之甚少的过程被招募。 7. ampk 和 mtor 的 ulk1 磷酸化. 人们早就知道 ulk1 的磷酸化是自噬调控的关键机制。

活跃的 ulk1 复合物随后转移到内质网的隔离膜上，自噬启动。 图 4. mtorc1 对 ulk1 复合物的调控作用[9] 2. 另外，ampk 也与自噬有关。在葡萄糖充足的情况下，活性 mtorc1 通过磷酸化 ulk1 特定位点 (ser 757) 并破坏 ulk1 与 ampk 之间的相互作用来阻止 ulk1 活化，抑制自噬 ...

Dec 25, 2024 · ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Diseases associated with ULK1 include Overnutrition and Neurodegeneration With Brain Iron Accumulation.Among its related pathways are Autophagy and Selective autophagy.Gene Ontology (GO) annotations related to this gene include transferase activity, transferring …

The ULK1 complex can regulate selective autophagy and is involved in numerous human pathologies. ULK1 kinase activity is a potential target for the development of treatments targeting autophagy in disease therapy. Acknowledgments. We thank the Ganley Laboratory for critical reading of the manuscript. Abbreviations ALS. amyotrophic lateral ...

Oct 15, 2021 · UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins. ULK1 has ...

此外，ulk1 已被广泛报道在人类疾病中发挥关键作用，包括癌症、神经退行性疾病、心血管疾病和感染，随后还证明了靶向小分子抑制剂或激活剂。有趣的是，ulk1的非自噬功能已经出现，表明非自噬相关的ulk1信号网络在某些特定情况下也与疾病有关。

Aug 9, 2018 · UNC-51-like kinase 1 (ULK1), known as an ortholog of the yeast Atg1, is the serine-threonine kinase and the autophagic initiator in mammals. Accumulating evidence has recently revealed the kinase domain structure of ULK1 and its post-translational modifications, as well as further elucidated its regulatory autophagic pathways and associations with diverse human …

Aug 28, 2018 · The Unc-51 like autophagy activating kinase 1 (ULK1) complex plays a central role in the initiation stage of autophagy. However, the function of ULK1 in the late stage of autophagy is unknown.