2017年7月14日 · What is UGT1A4? The UGT1A4 gene encodes an enzyme of the glucuronidation pathway, a phase II metabolism process that transforms small lipophilic …

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene. [5][6][7] This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation …

2024年12月25日 · UGT1A4 (UDP Glucuronosyltransferase Family 1 Member A4) is a Protein Coding gene. Diseases associated with UGT1A4 include Crigler-Najjar Syndrome, Type I and …

The main objective of this study was 1) to screen the UGT1A4 gene for polymorphisms in the promoter and coding region, from −4962bp relative to the transcription start site to 2000bp …

The UGT1A4 gene, located on chromosome 2q37.3, encodes a member of the UDP-glucuronosyltransferase (UGT) family of proteins. UGTs play a crucial role in detoxifying …

2025年2月19日 · Chinese patients with A/A or G/A genotype in the promoter region of bilirubin glucuronoside glucuronosyltransferase (UGT1A4) have a lower 5-year disease-free survival …

2024年12月10日 · UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems. Haslemo T, et al. Clin …

UGT1A4 is responsible for lamotrigine glucuronidation. During pregnancy, lamotrigine levels fall faster than in non-pregnant patients, which may be due to the activity of placental UGT1A4 …

2024年1月25日 · This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, …

Results: UGT1A4 (L48V) had higher enzyme efficiency (CL (int)) compared with wild-type UGT1A4 on DHT glucuronidation; UGT1A4 (P24T) and UGT1A4 (L48V) had lower CL (int) …