Feb 26, 2021 · Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, associated to fewer ethical, availability, and safety issues, position UC-MSCs as a promising active substance to develop medicinal products.

脐带间充质干细胞 (UC-MSC)和脐血造血干细胞 (UCB-HSC)的研究作为其中的一部分，具有广阔的临床应用前景。 UC-MSC和UCB-HSC是具有自我更新、分化能力和产生多系或单系特异细胞功能的细胞，位于细胞发育谱系的顶端。 笔者拟对UC-MSC和UCB-HSC的来源、生物学特点及其临床应用等方面的进展，综述如下。 引用本文: 冯磊, 曹宁, 梁素丽, 等. 脐带间充质干细胞与脐血造血干细胞临床应用的研究进展 [J/OL] . 中华妇幼临床医学杂志（电子版）, 2014, 10 (3) : 387-392. …

Apr 23, 2024 · Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising alternative, capitalizing on their low immunogenicity and potent immunomodulatory...

Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs). Apart from their prominent advantages, such as a painless collection procedure and faster self-renewal, UC-MSCs have shown the ability to differentiate into three germ ...

人脐带间充质干细胞（Human umbilical cord mesenchymal stem cells, HUC-MSCs）是指存在于新生儿脐带组织中的一种多能干细胞，具备较强的增殖、自我更新能力，并在一定条件下可分化成一种或多种人体组织或器官。 通过自体/异体移植可以重建组织器官的结构和功能，并且可避免免疫排斥反应。 正是由于HUC-MCSs所具备的这些免疫学特性，使其在自身免疫性疾病以及各种替代治疗等方面具有广阔的临床应用前景。 近年来，HUC-MCSs被医学界广泛的运用在各类疾 …

Jun 5, 2024 · 脐带间充质干细胞 (UC-MSC) 的来源多种多样，例如华顿胶、脐带内膜和脐带血管周围区域。 脐带通常作为医疗废物丢弃，但却是丰富且非侵入性获取的 MSC 储存库。 UC-MSC 的提取过程是非侵入性的，无需直接从患者身上获取细胞。 间充质干细胞是从捐赠的人类脐带中采购的。 与 BM-MSC 和 AD-MSC 相比，UC-MSC 表现出更高的增殖潜力，能够更有效地进行体外扩增并产生更多的细胞数量。 这些多能细胞可以分化成各种细胞类型，包括源自外胚层和中胚 …

In recent years, mesenchymal stromal cells (MSCs) have generated a lot of attention due to their paracrine and immuno-modulatory properties. mesenchymal stromal cells derived from the umbilical cord (UC) are becoming increasingly recognized as having increased therapeutic potential when compared to mesenchymal stromal cells from other sources.

Umbilical cord derived mesenchymal stem cells (UCMSCs) derived from the inner cell mass of the early stage human embryo possess immense regenerative potential owing to their pluripotent nature. This chapter displays a bird’s eye view of various applications and challenges of UCMSCs in regenerative medicine. Mengyuan Wang, ... Wenhua Xu.

Dec 5, 2016 · We found that UC-MSCs suppressed monocyte differentiation into DCs and instructed monocytes towards other cell types, with clear decreases in the expression of co-stimulatory molecules, in the...

Aug 3, 2020 · UC-MSCs apparently reduced the levels of pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) and pro-fibrotic factor (TGF-β) in the kidney and blood of DN rats. In vitro experiments showed that UC-MSC conditioned medium and UC-MSC-derived exosomes decreased the production of these cytokines in high glucose-injured renal tubular epithelial ...