2024年3月11日 · Tyrosine kinase 2 (TYK2), a Janus kinase family member, is involved in immune signalling and is implicated in autoimmune diseases such as systemic lupus erythematosus; inhibitors of TYK2...

Studies on Tyk2-deficient mice or human patients with mutated Tyk2 alleles have revealed that Tyk2 is a key player in the pathogenesis of autoimmune and/or inflammatory diseases. Imatinib, a Bcr-Abl kinase inhibitor, exerts potent therapeutic effects in …

Tyrosine kinase 2 (TYK2) is an intracellular enzyme that mediates immune signaling and inflammatory signaling pathways. 1-7 TYK2 is important in both innate and adaptive immune cells and is an essential component of

Tyk2 participates in the signaling of multiple regulatory and effector cytokines involved in psoriasis [10,44], and Tyk2 dysfunctional mutations are protective for psoriasis [10,22]. Thus, Tyk2 is an attractive druggable target, and multiple Tyk2 inhibitors are being investigated [10,13,22].

Learn more about the tyrosine kinase 2 (TYK2) pathway, its role in managing the inflammatory signals in psoriasis, and see the TYK2 pathway in action.

2024年11月11日 · Partial inhibition of TYK2 mitigates tau pathologies in cells and mice, highlighting TYK2 as a potential therapeutic target for Alzheimer’s disease and other tauopathies.

TYK2 is an enzyme that works inside the cell to mediate immune signals initiated by specific cytokines1 TYK2 and JAK1/2/3 typically work in pairs, or 'dimers' to relay signals from extracellular cytokines to the nucleus to regulate certain genes. TYK2 is selectively involved in the relay of signals from proinflammatory cytokines

2024年12月25日 · TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Overview of interferons-mediated signaling pathway and Interleukin-12 family signaling.

Here the authors review the evidence for targeting TYK2 as a more specific approach to treating these conditions. TYK2 inhibitors are clinically effective in autoimmune and inflammatory diseases and may avoid some of the complications reported with nonselective JAK inhibitors.

TYK2 is an intracellular kinase critical for the relay of immune signals initiated by proinflammatory cytokines such as IL-23, IL-12, and the Type I IFNs. Additional TYK2 pathway cytokines relevant to psoriatic arthritis (PsA) include IL-22 and IFN-λ. 23-25. IL-23 induces the production of both IL-17 and IL-22 26; IL-12 drives the production ...