Oct 18, 2023 · TRPM1 and TRPM3 are channels permeable to Ca 2+ and Zn 2+ regulated by neuroactive steroids that have crucial roles in ON-bipolar neurons of the retina, dorsal root ganglia neurons and other...

Feb 23, 2023 · TRPM3-related neurodevelopmental disorder (TRPM3-NDD) is characterized by congenital hypotonia, developmental delay, intellectual disability, seizures, and ophthalmologic and musculoskeletal manifestations.

TRPM3 is dynamically regulated by plasma membrane PI (4,5)P 2 and related PIPs. The transient receptor potential (TRP) channel TRPM3 is a calcium-permeable cation channel activated by heat and by the neurosteroid pregnenolone sulfate (PregS).

Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca 2+ permeable nonselective cation channel, activated by heat and chemical agonists, such as the endogenous neuro-steroid Pregnenolone Sulfate (PregS) and the chemical compound CIM0216.

Dec 25, 2024 · TRPM3 (Transient Receptor Potential Cation Channel Subfamily M Member 3) is a Protein Coding gene. Diseases associated with TRPM3 include Cataract 50 With Or Without Glaucoma and Neurodevelopmental Disorder With Hypotonia, Dysmorphic Facies, And Skeletal Anomalies, With Or Without Seizures.

Feb 26, 2021 · However, recent research identifies TRPM3 as an emerging new player in the brain. In this review, we summarize the available data regarding the roles of TRPM3 in the brain, and correlate these data with the neuropathological processes in which this …

Jan 14, 2025 · Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca 2+ -permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a...

Jan 17, 2023 · Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.

Feb 28, 2025 · The TRPM3 Foundation focuses on building community among patients and their families, caregivers, and healthcare providers, as well as funding of innovative research to accelerate treatment options and ultimately find a cure.

Feb 17, 2023 · TRPM3, unlike other TRPM channels, is activated by sphingosine (review by Farooqi et al., 2011). TRPM3 is activated by heat and is highly expressed in nociceptor neurons (summary by de Sainte Agathe et al., 2020).