TRPM is a family of transient receptor potential ion channels (M standing for wikt:melastatin). [1] Functional TRPM channels are believed to form tetramers. [2] The TRPM family consists of eight different channels, TRPM1–TRPM8. [3]

TRPM8 is an ion channel: upon activation, it allows the entry of Na + and Ca 2+ ions into the cell, which leads to depolarization and the generation of an action potential. The signal is conducted from primary afferents (type C- and A-delta) eventually leading to the sensation of …

Oct 18, 2023 · Melastatin-like transient receptor potential (TRPM) channels are multifunctional cation channels with diverse biophysical and physiological characteristics. Eight family members have...

Jul 5, 2023 · Transient receptor potential (TRP) channels, which were first discovered in 1969, 1 they are multimodal ion channels that act as sensors of chemically toxic and physical...

Dec 4, 2020 · The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been made in identifying novel members of the TRPM subfamily and their functions.

Menthol- and cold-evoked responses in sensory neurons and cells heterologously expressing TRPM8. (A) Whole-cell voltage clamp recordings from dissociated primary cultures of trigeminal neurons. Menthol (100 μM) and cold (see temperature plot) (more...)

Jan 1, 2020 · The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP cation channels. The TRPM subfamily is composed of eight members that are involved in diverse biological functions such as temperature sensing, inflammation, insulin secretion, and redox sensing.

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name. TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell.

Transient Receptor Potential Melastatin (TRPM) refers to a subtype of the TRP family of proteins that form cation-permeable pores and are involved in sensing a wide range of stimuli in various tissues and organs.

TRPM channels are abundantly expressed in the kidney. Mutations in TRPM genes cause several inherited human diseases, and preclinical studies in animal models of human disease have highlighted TRPM channels as promising new therapeutic targets.