
Tropomyosin receptor kinase B - Wikipedia
Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. [8]
TrkB Truncated Isoform Receptors as Transducers and ...
Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted growth factors and binds with high affinity to the TrkB tyrosine kinase receptors. BDNF is a critical player in the development of the central (CNS) and ...
TrkB transmembrane domain: bridging structural understanding ...
2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane …
The trkB Tyrosine Protein Kinase Is a Receptor for Brain ...
Summary. trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that encodes a receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3).trkB expression is confined to structures of the central and peripheral nervous systems, suggesting it also encodes a receptor for neurotrophic factors.
Regulation of BDNF-TrkB Signaling and Potential Therapeutic ...
Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic ...
TrkB signalling pathways in LTP and learning - Nature
In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways ...
Tropomyosin receptor kinase B (TrkB) signalling: targeted ...
Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor tyrosine kinase 2 (NTRK2) gene, and its abnormal activation caused by NTRK2 overexpression or fusion can contribut …