DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. [5][6] This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription.

2024年12月25日 · TOP2B (DNA Topoisomerase II Beta) is a Protein Coding gene. Diseases associated with TOP2B include B-Cell Immunodeficiency, Distal Limb Anomalies, And Urogenital Malformations and Agammaglobulinemia 4, Autosomal Recessive .

2022年11月2日 · Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic integrity in diverse dynamic processes such as transcription, replication, and cell division.

Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery. 1. Discovery of DNA Topoisomerase IIβ (TOP2B) Protein.

TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.

2024年2月27日 · We trapped catalytically engaged topoisomerase IIβ (TOP2B) in covalent DNA cleavage complexes (TOP2Bccs) and mapped their positions genome-wide in cultured mouse cortical neurons. We report that TOP2Bcc distribution varies with both nucleosome and compartmental chromosome organization.

This review will focus on one of the two mammalian type II DNA topoisomerase enzymes, DNA topoisomerase II beta (TOP2B), that have been implicated in correct execution of developmental transcriptional programs and in signal-induced transcription, including transcriptional activation by nuclear hormone ligands.

The TOP2B gene encodes a type II topoisomerase, an enzyme that generates transient DNA double-strand breaks to relieve topological stress during DNA replication and transcription (summary by Broderick et al., 2019 and Papapietro et al., 2020).

2019年8月13日 · TOP2B encodes a type II topoisomerase, an essential gene required to alleviate topological stress during DNA replication and gene transcription, with no previously known role in B cell...

2016年8月31日 · Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II beta (TOP2B) facilitates rapid gene expression and functions at …