Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene. [5] [6] [7] [8] TOM20 is one of the receptor systems of the translocase of the outer membrane (TOM) complex in the outer mitochondrial membrane.

Dec 25, 2024 · TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include Parkinson Disease 25, Autosomal Recessive Early-Onset, With Impaired Intellectual Development and Parkinson Disease 2, Autosomal Recessive Juvenile .

TOMM20 protein is highly expressed in both anaplastic thyroid cancer and papillary thyroid cancer compared to non-cancerous thyroid tissue. Tom20 was ubiquitously distributed in the organ of Corti, allowing well-delineated visualization of inner and outer hair cells.

Jan 5, 2025 · Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. Roche ME, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Dec 1. PMID 32920118, Free PMC Article.

Alternatively, immunocytochemical methods to label cells using antibodies against mitochondrial proteins [such as stress-70 protein (HSPA13), GRP75/HSPA9, or mitochondrial import receptor subunit TOM20 (TOMM20)] could be used to assess mitochondrial morphology and mass. In both cases, a relatively inert cytosolic dye such as calcein (in living ...

Mar 6, 2025 · Surprisingly, our study identified TOMM20, a mitochondrial outer membrane protein, as a potential molecular chaperone with similar roles to HSP90/HSP70. We found that TOMM20 expression is...

Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored.

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

TOMM20 is a member of the mitochondrial translocase of the outer membrane, which functions to shuttle mitochondrial-targeted proteins to the mitochondrial matrix (Omura, 1998) and has been implicated in pathophysiology of Parkinson's disease (Franco-Iborra et …

TOMM20 is a nuclear-encoded subunit of the mitochondrial translocation complex, which imports other nuclear-encoded proteins. TOMM20 is expressed on the outer mitochondrial membrane, and its globular cytosolic domain functions as a receptor that recognizes mitochondrial targeting signals on nuclear-encoded mitochondrial proteins (summary by ...