TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). [6] In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, [ 7 ] and pregnancy.

Dec 25, 2024 · TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Conjunctivochalasis . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway .

TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity. HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension. GnT-V-mediated aberrant N-glycosylation …

Dec 9, 2016 · Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating...

TIMPs were originally characterized as inhibitors of matrix metalloproteinases (MMPs), but their range of activities has now been found to be broader as it includes the inhibition of several of the disintegrin-metalloproteinases, ADAMs and ADAMTSs.

May 22, 2024 · Primary human and bone-marrow-derived DCs secrete TIMP-1, which notably increases MHC-I expression in classical type 1 dendritic cells (cDC1), especially under melanoma antigen exposure....

Sep 23, 2022 · From clinical evidence, TIMP-1 emerges as an important regulator of inflammatory processes. TIMP-1 is detected, at elevated levels, in the blood of patients with an exceptionally wide range of inflammation-associated diseases.

Feb 6, 2023 · Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor Protein (APP) family members, namely APP and Amyloid Precursor-like Protein-2 (APLP2), which was confirmed by pull-down assays and confocal microscopy.

Dec 10, 2024 · Title: TIMP1 promotes thyroid cancer cell progression through macrophage phenotypic polarization via the PI3K/AKT signaling pathway. TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity.

TIMP1 is a member of the TIMP family that regulates the pericellular proteolysis of extracellular matrix (ECM) and cell surface proteins by inhibiting metalloproteinases post-translationally. You might find these chapters and articles relevant to this topic.