TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). [6] In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, [ 7 ] and pregnancy.

2024年12月25日 · TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Conjunctivochalasis . Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway .

TIMPs were originally characterized as inhibitors of matrix metalloproteinases (MMPs), but their range of activities has now been found to be broader as it includes the inhibition of several of the disintegrin-metalloproteinases, ADAMs and ADAMTSs.

2016年12月9日 · Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating...

TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity. HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension. GnT-V-mediated aberrant N-glycosylation …

2023年2月6日 · Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor Protein (APP) family members, namely APP and Amyloid Precursor-like Protein-2 (APLP2), which was confirmed by pull-down assays and confocal microscopy.

2024年5月22日 · Primary human and bone-marrow-derived DCs secrete TIMP-1, which notably increases MHC-I expression in classical type 1 dendritic cells (cDC1), especially under melanoma antigen exposure....

2022年9月23日 · From clinical evidence, TIMP-1 emerges as an important regulator of inflammatory processes. TIMP-1 is detected, at elevated levels, in the blood of patients with an exceptionally wide range of inflammation-associated diseases.

Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a major player in preserving tissue integrity and has recently also emerged as a decisive factor in several human pathologies. This appreciation has prompted this review addressing the largely underestimated complexity of the functions executed by TIMP-1 and their mechanistic basis.

In this review, we summarized the current knowledge of TIMP-1 in several pulmonary diseases namely, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pneumonia, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and pulmonary fibrosis.