2024年12月25日 · TIMD4 (T Cell Immunoglobulin And Mucin Domain Containing 4) is a Protein Coding gene. Diseases associated with TIMD4 include Histiocytic Sarcoma and Cerebral Malaria. Among its related pathways is Ebola virus infection in …

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. [5] TIM-4 genes are in mouse present on chromosome 11B1.1 and in humans on chromosome 5q33.2.

2022年1月7日 · We confirmed that replacing TIMD4 (as the TLF subset marker) with either LYVE1 or FOLR2 identified a very similar, monocyte-independent macrophage subset in each organ (fig. S5D). Thus, the use of TIMD4 and CCR2 to stratify organ macrophage subpopulations reveals previously unrecognized differences in their life cycles.

T 细胞免疫球蛋白和粘蛋白结构域蛋白 4 (TIMD4, TIM4) 是 TIM 家族中的一个膜蛋白，是一种磷脂酰丝氨酸受体，在凋亡细胞的吞噬和 T 细胞调节等免疫应答中发挥不同的作用。 TIMD4 双模式地控制 T 细胞活化，并促进对凋亡细胞或外源颗粒的吞噬。 TIM-4/TIMD-4 蛋白, Human (HEK293, His) 是重组的 TIM-4/TIMD-4 蛋白，由 HEK293 表达，带有 C-6*His 标签。 TIM-4/TIMD-4 蛋白, Human (HEK293, His) 全长 291 个氨基酸，分子量为 60-90 kDa。 * Please select Quantity …

T细胞免疫球蛋白域与黏蛋白域4（T-cell immunogloblin domain and mucin domain 4， TIM-4）既是调控T细胞活化的共信号分子，也是凋亡细胞（小体）特征性膜分子磷脂酰丝氨 …

TIM-4 is considered to be a costimulatory molecule regulating T cell function and a phosphatidylserine receptor (PS) involved in the recognition of apoptotic cells (6, 21). Its functional characteristics change with expressing cells and sites.

TIM-4仅表达于抗原提呈细胞 (antigen-presenting cell，APC)包括活化的树突状细胞 (dendritic cell，DC)和巨噬细胞，TIM-4作为TIM-1天然配体，TIM-1-TIM-4相互作用参与辅助性T细胞 (helper T cells，Th)免疫调节和Th1/Th2细胞因子平衡调节，常出现在质膜脂双分子层的胞质区，在细胞凋亡开始时，它会翻动到外部起到对吞噬细胞 (巨噬细胞和DC)以及非吞噬细胞 (如上皮细胞)起到所谓的"eat me"信号的作用。 Miyanishi等 还研究发现TIM-4是磷脂酰丝氨酸 …

2025年2月8日 · TIM-4 in macrophages contributes to nasal polyp formation through the TGF-beta1-mediated epithelial to mesenchymal transition in nasal epithelial cells. Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.

Tim-4 expressing monocytes as a novel indicator to assess disease activity and severity of ulcerative colitis. Xue G, et al. Life Sci, 2021 Mar 15. PMID 33465392. TIMD4 exhibits regulatory capability on the proliferation and apoptosis of diffuse large B-cell lymphoma cells via the Wnt/β-catenin pathway.

Biased expression in lymph node (RPKM 8.4), testis (RPKM 2.6) and 5 other tissues. 预测启用磷脂酰丝氨酸结合活性。 预测作用于凋亡细胞清除的上游或内部。 预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable phosphatidylserine binding activity. Predicted to act upstream of or within apoptotic cell clearance.