Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature ...

2024年12月25日 · THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Retinal Artery Occlusion and Thymoma. Among its related pathways are Metabolism of proteins and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and GTPase activator activity.

Thy-1 (Thymocyte differentiation antigen 1), also known as CD90 (Cluster of Differentiation 90), is a highly conserved but somewhat enigmatic molecule that can exist in membrane-bound and soluble forms.

2004年9月15日 · Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation.

2020年5月1日 · Thy-1 plays vital roles in cell migration, adhesion, differentiation, transdifferentiation, apoptosis, mechanotransduction, and cell division, which in turn are involved in tumor development, pulmonary fibrosis, neurite outgrowth, and T cell activation.

Thy-1 细胞表面抗原： 该基因编码细胞表面糖蛋白和免疫球蛋白超家族的成员。 编码的蛋白质参与许多细胞类型的细胞粘附和细胞通讯，但特别是在免疫和神经系统的细胞中。

2006年10月1日 · Thy-1 interacts with both integrins and cytoplasmic tyrosine kinases to promote cell adhesion. Thy-1 appears to inhibit cellular migration at baseline, but it may facilitate regulated migration in response to injury, via both tyrosine kinase- and lipid raft-dependent mechanisms.

We identified Thy-1 as a surface marker of cancer stem cells in ovarian cancer and further demonstrated increased proliferative and self-renewal capability in Thy-1 expressing cells that was reversible with Thy-1 knockdown.

2013年1月28日 · Using epitope-tagged recombinant soluble Thy-1, we report that widely available monoclonal antibodies to human Thy-1 are unable to detect soluble Thy-1 by immunoblotting.

2004年9月15日 · Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation.