2024年12月25日 · TGFBR1 (Transforming Growth Factor Beta Receptor 1) is a Protein Coding gene. Diseases associated with TGFBR1 include Multiple Self-Healing Squamous Epithelioma and Loeys-Dietz Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Loss of Function of TGFBR2 in Cancer.

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. TGFBR1 is its human gene.

TGF-β的命名是根据这种细胞因子能使正常的成纤维细胞的表型发生转化，即在表皮生长因子（EGF）同时存在的条件下，改变成纤维细胞贴壁生长特性而获得在琼脂中生长的能力，并失去生长中密度信赖的抑制作用而来。 TGF-β信号在早期胚胎发育与组织器官形成、免疫监督、组织修复与成体稳态平衡中发挥重要作用。 TGF-β信号转导异常则可能导致多种疾病的发生，比如胚胎发育异常、肿瘤、组织纤维化、心血管疾病和免疫性疾病等。

2024年2月13日 · Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control...

TGF-β ligands bind to three isoforms of the TGF-β receptor (TGFBR) with different affinities. TGFBR1 and 2 are both serine/threonine and tyrosine kinases, but TGFBR3 does not have any kinase activity. They are necessary for activating canonical or noncanonical signaling pathways, as well as for regulating the activation of other signaling pathways.

转化生长因子 β (TGF-β) 超家族信号转导在众多生物系统中对细胞生长、分化和发育的调节发挥重要作用。 一般而言，信号转导起始于配体诱导的丝氨酸/苏氨酸受体激酶寡聚化和胞浆信号转导分子的磷酸化，这些信号转导分子在 TGF-β/活化素通路中是 Smad2 和 Smad3，而在骨形态发生蛋白 (BMP) 通路中则是 Smad1/5/9。 Smads 的羧基端被活化受体磷酸化后导致其与常见信号转导因子 Smad4 结合，并转运入胞核。 激活的 Smads 可通过与转录因子结合，调节各种不同的生 …

Functional activation of the transforming growth factor-β (TGF-β) receptors (TGFBRs) is carefully regulated through integration of post-translational modifications, spatial regulation at the cellular level, and TGFBR availability at the cell surface.

2024年12月25日 · TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are Loss of Function of TGFBR2 in Cancer and TGF-beta receptor signaling activates SMADs.

2018年12月1日 · Dysregulation of TGF-β responsiveness and its downstream signaling pathways contribute to many diseases, including cancer initiation, progression, and metastasis. TGF-β ligands bind to three isoforms of the TGF-β receptor (TGFBR) with different affinities.

由该基因编码的蛋白质在与 TGF-β 结合时与 II 型 TGF-β 受体形成异聚复合物，将 TGF-β 信号从细胞表面转导至细胞质。 编码的蛋白质是丝氨酸/苏氨酸蛋白激酶。 该基因的突变与 Loeys-Dietz 主动脉瘤综合征 (LDAS) 有关。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提 …