Dec 25, 2024 · TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Gastric Cardia Adenocarcinoma and Lung Cancer. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

Transcription factor 7 (TCF7) plays an essential role in Wnt signaling by interacting with β-catenin. Emerging evidence demonstrates that overexpression of TCF7 promotes progression or correlates with poor progression in several types of cancers, ...

We identified and validated the HMG box protein TCF7 as a regulator in this self-renewal/differentiation switch that operates in the absence of autocrine Wnt signaling. We found that Tcf7 is the most down-regulated transcription factor when CD34+ cells switch into CD34- cells, using RNA-Seq.

Feb 8, 2025 · Title: LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p. Pancreatic stellate cells exploit Wnt/beta-catenin/TCF7-mediated glutamine metabolism to …

We identified and validated the HMG box protein TCF7 as a regulator in this self-renewal/differentiation switch that operates in the absence of autocrine Wnt signaling. We found that Tcf7 is the most down-regulated transcription factor when CD34+ cells switch into CD34− cells, using RNA–Seq.

We identify two novel genes TCF7 and XCL1 derived from public single-cell-sequencing database of patients with atherosclerosis. These genes participate in proinflammatory signaling (regulated by NFκB/AKT).

May 28, 2019 · Emerging evidence demonstrates that overexpression of TCF7 promotes progression or correlates with poor progression in several types of cancers, but the functions of TCF7 in gastric cancer (GC) have not been revealed.

Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury. Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta ...

Jun 1, 2003 · The T-cell–specific transcription factor TCF7 activates genes involved in immune regulation and is a candidate locus for genetic susceptibility to type 1 diabetes. A nonsynonymous single nucleotide polymorphism (SNP) (Pro to Thr) in the TCF7 gene, C883A, was examined in samples from 282 Caucasian multiplex type 1 diabetic families.

Oct 30, 2020 · Central memory CD8 + T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew.