2024年12月25日 · TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Gastric Cardia Adenocarcinoma and Lung Cancer. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

21414 Ensembl ENSG00000081059 ENSMUSG00000000782 UniProt P36402 Q00417 RefSeq (mRNA) NM_001134851 NM_001134852 NM_003202 NM_201632 NM_201634 NM_213648 NM_001346425 NM_001346450 NM_001366502 NM_009331 NM_001313981 RefSeq (protein) NP_001128323 NP_001333354 NP_001333379 NP_003193 NP_963963 NP_963965 …

2025年2月8日 · Title: LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p. Pancreatic stellate cells exploit Wnt/beta-catenin/TCF7-mediated glutamine metabolism to …

We identified and validated the HMG box protein TCF7 as a regulator in this self-renewal/differentiation switch that operates in the absence of autocrine Wnt signaling. We found that Tcf7 is the most down-regulated transcription factor when CD34+ cells switch into CD34- cells, using RNA-Seq.

We identified and validated the HMG box protein TCF7 as a regulator in this self-renewal/differentiation switch that operates in the absence of autocrine Wnt signaling. We found that Tcf7 is the most down-regulated transcription factor when CD34+ cells switch into CD34− cells, using RNA–Seq.

Transcription factor 7 (TCF7) plays an essential role in Wnt signaling by interacting with β-catenin. Emerging evidence demonstrates that overexpression of TCF7 promotes progression or correlates with poor progression in several types of cancers, ...

TCF7 is important for T cell development and differentiation, embryonic development, or tumorogenesis. Multiple TCF7 isoforms can be characterized by the full-length isoform (FL-TCF7) as a transcription activator, or dominant negative isoform (dn-TCF7) as a transcription repressor.

Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury. Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta ...

2019年5月28日 · Emerging evidence demonstrates that overexpression of TCF7 promotes progression or correlates with poor progression in several types of cancers, but the functions of TCF7 in gastric cancer (GC) have not been revealed.

2023年11月23日 · LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p. Tcf-1 protects anti-tumor TCR-engineered CD8⁺ T-cells from GzmB mediated self-destruction.

2020年10月30日 · Central memory CD8 + T cells (Tcm) control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew.

2011年10月25日 · Forcible expression of human TCF7 in mouse bone marrow progenitors drove development of T-lineage cells in the absence of Notch1 signals. These Tcf7-induced cells expressed T-cell-specific transcription factors, such as Gata3 and Bcl11b , as well as T-cell receptor components, such as Cd3e.

2015年8月20日 · Transcription factors such as transcription factor 7 (TCF7) are involved in the pathogenesis of lung diseases. TCF7 is important for T cell development and differentiation, embryonic development, or tumorogenesis.

2022年5月17日 · In this manuscript we utilized a pre-clinical model provided evidence that TCF-7 is dispensable for the anti-tumor response, and that TCF-7 suppresses key transcriptional factors Eomes and T-bet and molecules responsible for peripheral CD8 T cell cytolytic function.

The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional ...

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2025年2月8日 · transcription factor 7, T-cell-specific transcription factor 1. TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma. Downregulation of TCF7 and LEF1 is a key determinant of tumor-infiltrating regulatory T …

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