Understanding how Tcf1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. This review discusses Tcf1, which plays context-dependent roles in T cell function during autoimmunity, cancer, and chronic infection.

2021年10月6日 · Although it has mostly been associated with positive regulation of chromatin accessibility and gene expression, TCF-1 has the potential to reduce chromatin accessibility and thereby suppress gene...

2021年6月14日 · In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8 + T cells generated in response to viral or tumour antigens, and for preserving heightened responses to...

In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8 + T cells generated in response to viral or tumour antigens, and for preserving heightened responses to checkpoint blockade immunotherapy.

Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. T cell factor 1 (TCF1, encoded by Tcf7) is the key transcription factor of the canonical WNT signaling pathway (Fig. 1A).

The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain.

2024年11月27日 · Loss-of-function studies have shown that transcription factor T cell factor-1 (TCF1), encoded by the Tcf7 gene, is essential for T cell development in the thymus. We discovered that the Tcf7 expression level is regulated by E box DNA binding proteins, independent of Notch, and regulates αβ and γδ T cell development.

Moreover, TCF-1 is a potential biomarker of CD8 + T cell functionality to predict the efficacy of immunotherapy in fighting against cancer and infections. Herein, we summarize the role of TCF-1 in T cell development and its applications in the treatment of cancer and infectious diseases.

TCF-1 co-binds accessible regulatory regions containing or lacking its conserved motif and cooperates with other nuclear factors to establish context-dependent epigenetic and transcription programs that are essential for T cell development and for regulating immune responses to infection, autoimmunity and cancer.

2021年8月12日 · Here, we show that TCF-1 primarily suppresses transcription of genes that are co-bound by Foxp3. Single-cell RNA-sequencing analysis identified effector memory T cells and central memory T reg...