A sequential one-pot synthesis for the oxidation of primary and secondary tert-butyldimethylsilyl (TBDMS) ethers, using the presence of PhIO or PhI(OAc) 2 and catalytic amounts of metal triflates and TEMPO in THF or acetonitrile tolerates acid-sensitive protecting groups and leaves tert-butyldiphenylsilyl ethers and phenolic TBDMS groups untouched.

What is the TBS Protecting Group? TBS or TBDMS is short for tert – b utyl d i m ethyl s ilyl, a protecting group for alcohols. TBS was introduced by the legendary E. J. Corey in 1972 [1] as an evolution to simpler silyl ethers which had already been known.

Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

tert -Butyldimethylsilyl chloride (TBDMSCl) is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. [1] [2] It is also used in the preparation of isoxazoline N -oxides from α-bromonitroalkanes and olefins. [3] .

2025年2月24日 · tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes.

叔丁基二甲基硅基（TBS），是常用的 硅醚 保护基 之一，用于羟基的保护。 中文全称为叔丁基二甲基硅基，通常都直接使用英文缩写TBS。 该方法由 艾里亚斯·詹姆斯·科里 （Elias James Corey）首先使用。 上保护基的常用方法 用 TBDMS-Cl 和恶唑于室温 DMF 溶剂中处理即可，对伯醇的产率相当高。 该法对 仲醇 则很慢，产率欠佳，可用 TBDMSOTf/TEA 来上保护基。 去保 …

All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. Please see the following for information about the library and its accompanying search program. Go To: Top, Mass spectrum (electron ionization), Notes. Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A.

Protocatechuic acid, TBDMS | C25H48O4Si3 | CID 528594 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Arg, TBDMS | C30H70N4O2Si4 | CID 529516 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2006年8月14日 · Protection of hydroxyl groups and subsequent deprotection are frequently applied in multistep transformations and syntheses of complex organic molecules. 1 The t-butyldimethylsilyl (TBDMS) group is widely used as a hydroxyl protecting group as it can easily be introduced and can withstand a variety of reaction conditions. 2 Cleavage of TBDMS ...