Dec 25, 2024 · Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3.

May 3, 2021 · We identify a novel T cell inhibitory molecule TAPBPL that shares sequence and structural homology with existing B7 family members. TAPBPL protein is expressed on APCs and cancer cells. The TAPBPL receptor is expressed on activated CD4 and CD8 T cells. Recombinant hTAPBPL‐Ig protein inhibits the proliferation and activation of T cells in ...

May 7, 2021 · In this study, we identify a novel T cell co-inhibitory molecule TAPBPL, whose amino acid sequence shares homology with known B7 family members. TAPBPL protein is expressed on resting and activated T cells, B cells, monocytes, and dendritic cells (DCs), as well as on some tumor tissues.

Sep 7, 2023 · We have previously identified a novel immune checkpoint molecule, TAPBPL, that inhibits T cell functions in vitro. As a model for human RA, we investigated the ability of the TAPBPL protein to ameliorate collagen type II (CII)-induced arthritis (CIA) in mice that were injected with recombinant TAPBPL or a control protein.

The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]... show less

Feb 8, 2025 · Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3.

Tapasin，或 TAPBP (MIM 601962) ，是可变常数 Ig 超家族的成员，它将主要组织相容性复合体 (MHC) I 类分子连接到内质网 (ER) 中与抗原加工相关的转运体 (TAP；参见 MIM 170260) ) . TAPBP 基因位于染色体 6p21.3 上的 MHC 复合体附近。 TAPBPL 是位于染色体 12p13.3 上的 Ig 超家族成员，该区域与 MHC 有点相似。 [OMIM 提供，2008 年 3 月]

May 7, 2018 · Tapasin, or TAPBP (601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3.

May 3, 2021 · In this study, we identify a novel T cell co-inhibitory molecule TAPBPL, whose amino acid sequence shares homology with known B7 family members. TAPBPL protein is expressed on resting and...

Jun 1, 2023 · Based on five identified plasma proteins, four available corresponding gene candidates showed consistent associations with multiple sclerosis risk in whole-blood, and we found TAPBPL upregulation in multiple sclerosis B cells, CD8+ T cells and natural killer cells compared with controls.