2024年12月25日 · TAOK2 (TAO Kinase 2) is a Protein Coding gene. Diseases associated with TAOK2 include Dyskeratosis Congenita, Autosomal Dominant 6 and Autism Spectrum Disorder. Among its related pathways are VEGFA-VEGFR2 signaling and MAPK signaling pathway.

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene. [5] [6] [7]

2018年2月21日 · Whole-genome and -exome sequencing of ASD families identified three de novo mutations in TAOK2 and functional analysis in mice and human cells revealed that all the mutations impair protein...

TAOK2 is an ER kinase that directly binds microtubules, coupling ER to microtubules. Loss of TAOK2 increases ER and microtubule dynamics. TAOK2 associates with EB1 and STIM1 to regulate ER movement on microtubule plus ends. Catalytic activity of TAOK2 drives untethering of ER from the mitotic spindle Nourbakhsh et al., 2021, Developmental Cell ...

2024年4月12日 · Here, we use proteomics, genetics, and translation assays in cultured cells and mouse brain to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models. We show that TAOK2 associates with the translational machinery and functions as a translational brake by phosphorylating eukaryotic elongation factor 2 (eEF2).

taoks共有三个成员: taok1、taok2和taok3, 其结构域均高度保守, 广泛表达于多种细 胞和组织。作为丝裂原活化蛋白激酶(MAPK)级联的上游激酶, TAOKs通过p38 MAPK和JNK/SAPK

TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively.

TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to NDDs is unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and knockout (KO) mice and found gene dosage-dependent impairments in cognition, anxiety, and …

2017年1月18日 · We show that TAOK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an evolutionary conserved residue. This phosphorylation induces translocation of Septin7 to the spine, where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine maturation.

该基因编码参与许多不同过程的丝氨酸/苏氨酸蛋白激酶，包括细胞信号传导、微管组织和稳定性以及细胞凋亡。 已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2011 年 10 月] This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and Apoptosis.