Dec 25, 2024 · TSC1 (TSC Complex Subunit 1) is a Protein Coding gene. Diseases associated with TSC1 include Tuberous Sclerosis 1 and Lymphangioleiomyomatosis. Among its related pathways are MTOR signalling and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include binding and protein-folding chaperone binding.

Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene. [5] TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle.

Jan 14, 2021 · 结节性硬化症蛋白复合体 （Tuberous Sclerosis Complex, 简称 TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。 TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形式的Rheb，导致Rheb失活，不能激活mTORC1的激酶活性，抑制细胞生 …

TSC1, an essential component of the pro-survival PI3K/AKT/MTOR signaling pathway, plays an important role in processes like development, cell growth and proliferation, survival, autophagy and cilia development by co-operating with a variety of regulatory molecules.

TSC1, an essential component of the pro-survival PI3K/AKT/MTOR signaling pathway, plays an important role in processes like development, cell growth and proliferation, survival, autophagy and cilia development by co-operating with a variety of regulatory molecules.

Jan 14, 2021 · 结节性硬化症蛋白复合体（Tuberous Sclerosis Complex, 简称TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。

Tuberous sclerosis proteins 1 and 2, also known as TSC1 (hamartin) and TSC2 (tuberin), form a protein-complex. The encoding two genes are TSC1 and TSC2. The complex is known as a tumor suppressor. Mutations in these genes can cause tuberous sclerosis complex.

这种 hamartin-tuberin 复合物负向调节哺乳动物雷帕霉素靶标复合物 1 (mTORC1) 信号，后者是合成代谢细胞生长的主要调节因子。 这种蛋白质还充当 HSP90 的辅助伴侣，抑制其 ATP 酶活性。 这种蛋白质作为 HSP90 介导的激酶和非激酶客户折叠的促进剂，包括 TSC2，从而防止它们的泛素化和蛋白酶体降解。 该基因的突变与结节性硬化症和淋巴管平滑肌瘤病有关。 [RefSeq 提供，2022 年 5 月] This gene is a tumor suppressor gene that encodes the growth inhibitory …

与结节性硬化症1有关的重要基因是TSC1（TSC复合物亚单位1），其相关通路/超级通路包括前列腺癌中的雄激素受体网络和整合性乳腺癌通路。 在该疾病的背景下提到了多西环素和大麻二酚。 附属组织包括皮肤和大脑，相关表型为癫痫发作和皮肤的普遍异常。 IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis.

Jan 14, 2021 · 结节性硬化症蛋白复合体（Tuberous Sclerosis Complex, 简称TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。 TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称...