Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene.

TRPV4 is one of the most extensively investigated TRP channels due to its widespread expression and multifaceted roles across various systems, including the peripheral and central nervous systems, immune cells, cardiovascular system, urinary system, digestive tissues, and the respiratory tract [18, 19, 26]. On a single-cell level, the highest ...

Transient Receptor Potential (TRP) channels are a family of ion channels whose members are distributed among all kinds of animals, from invertebrates to vertebrates. The importance of these molecules is exemplified by the variety of physiological roles they play.

The TRPV4 gene provides instructions for making a protein that acts as a calcium channel. This channel, which transports positively charged atoms of calcium (calcium ions) across cell membranes, is found in many types of cells and tissues.

TRPV4, the fourth member of the vanilloid subfamily of TRP channels, is a calcium-permeable cation channel that is detectable in both sensory and nonsensory cells. It has been shown to be widely expressed, including in kidneys, lungs, hearts, brains, endothelial cells, and dorsal root and trigeminal sensory ganglia.

The expression of TRPV4 in tissues that show flow- or shear stress-dependent Ca 2+ entry like flow-sensitive nephron segments and the vascular endothelium make TRPV4 a candidate for a channel sensitive to these stimuli.

Dec 25, 2024 · TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a Protein Coding gene. Diseases associated with TRPV4 include Metatropic Dysplasia and Hereditary Motor And Sensory Neuropathy, Type Iic. Among its related pathways are Ion channel transport and CREB Pathway.