Dec 25, 2024 · Complete information for TRIM28 gene (Protein Coding), Tripartite Motif Containing 28, including: function, proteins, disorders, pathways, orthologs, and expression.

Jan 16, 2025 · We show that CD8 + T-cell-specific deletion of Trim28 in mice disrupts autocrine IL-2 production and leads to impaired CD8 + T cell activation in vitro and in vivo. Mechanistically, TRIM28 binds...

TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation.

Here, we present distinct aspects of TRIM28 involvement in regulation of cancer cell homeostasis which collectively imply pro-tumorigenic character of TRIM28. Thorough analyses are further needed to verify whether TRIM28 possess the potential to become a new anti-cancer target.

Jul 19, 2024 · TRIM28 (tripartite motif protein 28) was initially believed to be a transcription inhibitor that plays an important role in DNA damage repair (DDR) and in maintaining cancer cellular stemness.

TRIM28, also known as KRAB-associated protein 1 (KAP1) and transcription intermediary factor 1β (TIF1β), has been reported to be a transcriptional corepressor for some transcription factors, in particular for the Krüppel-associated box domain–containing zinc-finger transcription factors (KRAB-ZFPs) (47, 48).

Aug 29, 2017 · Here, we present distinct aspects of TRIM28 involvement in regulation of cancer cell homeostasis which collectively imply pro-tumorigenic character of TRIM28. Thorough analyses are further needed to verify whether TRIM28 possess the potential to become a new anti-cancer target.

Feb 8, 2025 · Data indicate a mechanism in breast cancer cells that tripartite motif-containing 28 protein (TRIM28) enhances metastasis by stabilizing TWIST1, suggesting that targeting TRIM28 could be an efficacious strategy in breast cancer treatment.

Aug 21, 2015 · TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation.

Aug 31, 2014 · Promoter-proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in transcription. An unbiased search for new human proteins that could regulate paused Pol II at the HSPA1B gene...