Dec 25, 2024 · TRAF3 (TNF Receptor Associated Factor 3) is a Protein Coding gene. Diseases associated with TRAF3 include Encephalopathy, Acute, Infection-Induced 5 and Candidiasis, Familial, 6. Among its related pathways are Toll Like Receptor 7/8 …

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene. [5][6][7] The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily.

traf3是一个在抗病毒免疫中引导干扰素产生的调控者 。但traf3是如何传导刺激的讯息仍不为所知。新研究指出丝氨酸-苏氨酸激酶ck1ε可将traf3磷酸化，进而促进其泛素化，以诱导β干扰素的产生。

traf3是既可以介导nf-κb经典信号通路，也可以介导非经典信号通路。 在经典信号通路中， 其可以与受体直接作用激活IKK复合物。 而在非经典信号通路中， TRAF3通过NIK（NF-κB诱导激酶）激活IKKα，从而激活信号通路。

TRAF3 is one of the most diverse members of the TRAF family. It can positively regulate type I interferon production while negatively regulating signaling pathways of classical nuclear factor-κB, nonclassical nuclear factor-κB, and mitogen-activated protein kinase (MAPK). This review summarizes the roles of TRAF3 signaling and the related ...

MAVS 二聚化会通过分别与 TRAF 互作基序和 TRAF 结构域的相互作用，实现 TNF 受体-相关因子 3 (TRAF3) 结合。 反过来，TRAF3 会募集接头蛋白 TANK、NAP1 和 SINTBAD。 TANK 可将上游 RLR 信号转导连接至 TANK 结合激酶 1 (TBK1)，TBK1 会诱导干扰素调节因子 3 (IRF-3) 的磷酸化。 IRF-3 磷酸化和随后的二聚化会诱导 IRF-3 核转位，IRF-3 随后结合干扰素刺激应答元件 (ISRE)，从而导致 I 型干扰素基因表达。 胞质双链 DNA 检测也通过多个入口流入 TBK1-IRF …

TRAF proteins associate with, and mediate the signal transduction from, members of the TNF Receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response.

这些TRAF成员在C末端有螺旋卷曲结构和保守的TRAF结构域.TRAF3是TRAF家族中功能最为多样化的成员之一.1996年对TRAF3基因敲除小鼠进行研究发现,小鼠在出生早期死亡，这阻碍了TRAF3的生物学功能进一步研究，另一方面也证实了TRAF3在出生后发育以及维持正常的免疫系统功能方面有着重要生物学功能.10年后研究发现,TRAF3的缺失能够导致非经典NF-&kapp...

Jun 10, 2011 · Recent work has revealed that TRAF3 is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein kinase activation and...

Apr 10, 2015 · traf3 在诱导 tlr 信号通路中Ⅰ型干扰素的作用， 通过研究表明，缺失 TRAF3 的细胞系在接受不同 TLR 配体刺激的条件下都不能够产生Ⅰ型干扰素，