Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. [5] TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family.

2024年3月27日 · We demonstrate a novel cascade of learning-induced molecular events in discrete neuronal clusters undergoing dsDNA damage and TLR9-mediated repair, resulting in their recruitment to memory...

TLR9 is a receptor that recognizes specific DNA motifs found in both bacterial and viral DNA, and has the potential to be targeted for adjuvants. Recent studies suggest that TLR9 may play a role in the production of autoantibodies, which are antibodies that target self-components.

2022年7月28日 · Toll-like receptor 9 (TLR9) agonists have been extensively investigated as therapeutics in monotherapy or combination therapies for the treatment of cancer, infectious diseases and...

Toll like receptor 9 (TLR9) has been considered as a crucial intracellular pattern recognition receptor in the immune system, which can directly or indirectly mediate innate and adaptive immune responses by recognizing CpG DNA in endosomes to initiate its downstream signaling.

2024年12月25日 · TLR9 (Toll Like Receptor 9) is a Protein Coding gene. Diseases associated with TLR9 include Cervicitis and Measles. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Insulin receptor signalling cascade. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and siRNA binding.

2024年1月2日 · Here, we report that palmitoyl-protein thioesterase 1 (PPT1) regulates systemic autoimmunity by removing S-palmitoylation from TLR9 in lysosomes. PPT1 promotes the secretion of IFNα by...

2024年4月9日 · Cell surface TLRs (TLR1, TLR2, TLR4, and TLR5) recognize lipid and protein components, whereas endosomal TLRs (TLR3, TLR7, TLR8, TLR9, and TLR13) specialize in nucleic acid detection.

Toll-like receptor 9 (TLR9) plays a fundamental role in innate immune responses through pathogen-associated and danger-associated molecular pattern recognition.

2022年10月15日 · Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells. Release of cellular components, such as proteins, nucleotides, and DNA confers a beneficial inflammatory response and maintains homeostasis for removing cellular debris during normal physiological conditions.