THP-1 is a suspension cell line isolated from peripheral blood of an acute monocytic leukemia patient. Depending on culture conditions, these cells can differentiate into macrophages and dendritic cells.

THP-1 is a human leukemia monocytic cell line, which has been extensively used to study monocyte/macrophage functions, mechanisms, signaling pathways, and nutrient and drug transport. This cell line has become a common model to estimate modulation of monocyte and macrophage activities.

THP-1 cells, including their genetically engineered derivatives, represent valuable tools for investigating monocyte structure and function in both health and disease.

Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Lineage infidelity of a human myelogenous leukemia cell line. Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.

THP-1 is a human leukemia monocytic cell line, which has been extensively used to study monocyte/macrophage functions, mechanisms, signaling pathways, and nutrient and drug transport. This cell line has become a common model to estimate modulation of monocyte and macrophage activities.

2015年8月8日 · mRNA and protein expression of M1 and M2 markers confirmed the polarization of THP-1-derived macrophages, which provide a new, easy and well-characterized model of polarized human macrophages.

We have implemented an improved, cost-effective, and highly reproducible protocol for a simple and rapid differentiation of the human leukemia monocytic cell line THP-1 into surrogates for immature dendritic cells (iDCs) or mature dendritic cells (mDCs).

THP-1 cells are a monocyte-like cell line derived from a patient with acute monocytic leukemia and unlike other leukemic cell lines has a normal diploid karyotype. We have characterized Fc gamma R expression on this cell line by flow cytometry, radiolabeled IgG1 and monoclonal antibody (mAb) binding …

THP-1细胞为悬浮细胞，相比于ML-2、HL-60、U937等白血病细胞系，THP-1细胞具有更接近于人原代单核细胞的形态和功能特征（包括细胞分化标记）。 并且相对于人外周血单核细胞（PBMC），THP-1更易在实验室中培养和扩增，且具有更稳定的基因背景，不存在PBMC的个体差异性问题，利于实验结果的重现。 因此，THP-1是各大实验室常用的急性单核细胞白血病细 …

2020年3月1日 · Here we present protocols that can be used to prepare M (IL-4) polarized THP-1 that transcribe CCL17, CCL26, CD200R and MRC1 and M (IL-10) cells which transcribe CD163, C1QA and SEPP1.