Treacle Ribosome Biogenesis Factor 1 (TCOF1) also known as Treacle is a protein that in humans is encoded by the TCOF1 gene. [5] [6] TCOF1 encodes a nucleolar protein with an …

Treacher Collins syndrome (TCS) is an autosomal dominant disorder characterized by an abnormality of craniofacial development that arises during early embryogenesis. TCS is …

2024年12月25日 · TCOF1 (Treacle Ribosome Biogenesis Factor 1) is a Protein Coding gene. Diseases associated with TCOF1 include Treacher Collins Syndrome 1 and Crouzon …

The TCOF1 gene provides instructions for making a protein called treacle. This protein is active during early embryonic development in structures that become bones and other tissues of the …

Data indicate that Treacher Collins-Franceschetti syndrome 1 protein (TCOF1) was the main disease-causing gene for the Chinese Treacher Collins syndrome (TCS) population and its …

2021年3月1日 · Among all nucleolar proteins, treacle encoded by TCOF1 gene emerges as one of the most crucial regulators of cellular processes. TCOF1 was initially discovered as a gene …

HGNC Approved Gene Symbol: TCOF1. By positional cloning, the Treacher Collins Syndrome Collaborative Group (1996) identified a novel gene of unknown function, which they …

Tcof1 regulates ribosome biogenesis for neural crest cell survival. Treacle co-localizes with upstream binding factor (UBF) and RNA polymerase I in the nucleolus where ribosomal RNA …

2020年10月20日 · Here, we report that TCOF1 leaves the nucleolus and is recruited to telomeres specifically during S phase by interacting with TRF2. Therein, TCOF1 acts to suppress …

2024年1月7日 · TCOF1 coordinates oncogenic activation and rRNA production and promotes tumorigenesis in HCC. TCOF1 upregulation in triple-negative breast cancer promotes …

The TCOF1 gene product, treacle, responsible for the craniofacial disorder Treacher Collins syndrome, has been predicted to be a member of a class of nucleolar phosphoproteins based …

TCOF1 is a prognostic marker in Liver hepatocellular carcinoma, Lung adenocarcinoma

About 200 mutations in the TCOF1 gene have been identified in people with Treacher Collins syndrome, a condition that affects the development of bones and other tissues of the face.

Treacle ribosome biogenesis factor 1 (TCOF1) is a nucleolar factor that regulates ribosomal DNA (rDNA) transcription in the nucleolus. TCOF1 has been previously reported to be implicated in …

2021年3月1日 · Among all nucleolar proteins, treacle encoded by TCOF1 gene emerges as one of the most crucial regulators of cellular processes. TCOF1 was initially discovered as a gene …

2025年2月7日 · Our findings establish TCOF1 as the primary pathogenic gene in this Chinese TCS cohort, with mutations predominantly in the CRD and CTD, thereby expanding the known …

Tcof1 regulates ribosome biogenesis for neural crest cell survival. Treacle co-localizes with upstream binding factor (UBF) and RNA polymerase I in the nucleolus where ribosomal RNA …

2004年7月20日 · Treacher Collins syndrome (TCS) is an autosomal dominant disorder characterized by an abnormality of craniofacial development that arises during early …

2022年1月30日 · Treacle ribosome biogenesis factor 1 (TCOF1) plays a crucial role in multiple processes, including ribosome biogenesis, DNA damage response (DDR), mitotic regulation, …

2021年3月1日 · TCOF1 was initially discovered as a gene involved in the Treacher Collins syndrome, a rare genetic disorder characterized by severe craniofacial deformations. Later …