Dec 25, 2024 · TCF7L2 (Transcription Factor 7 Like 2) is a Protein Coding gene. Diseases associated with TCF7L2 include Type 2 Diabetes Mellitus and Autism. Among its related …

TCF7L2 regulates adipocyte size, adipocyte endocrine function, and glucose metabolism. TCF7L2 expression in white adipose tissue is suppressed in genetic and high fat diet–induced models …

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a …

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR. TCF7L2 plays a complex role in human adipose progenitor biology, which …

TCF7L2, the susceptibility gene with the largest effect on disease susceptibility discovered to date, was identified pre–genome-wide association by Grant et al. in 2006, with rapid …

TCF7L2 is a transcriptional regulator of the canonical Wnt‐signaling pathway, a major transducer of β‐catenin activity. It also regulates cell fate specification during development and cell …

Feb 8, 2025 · Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway. Astrocytic beta-catenin …

Oct 5, 2023 · Here, we show that TCF7L2, which is a key transcriptional effector of the Wnt/β-catenin pathway, plays a cell-autonomous role in postnatal astrocyte maturation and impacts …

Jul 11, 2014 · Tcf7l2 is a key regulator of proinsulin production and processing. Twelve analyzed genes involved in proinsulin synthesis were downregulated in Tcf7l2 silenced cells, including …

Dec 15, 2014 · Using RNA-sequencing, we have identified a TCF7L2-regulated transcriptional network responsible for its effect on insulin secretion in rodent and human pancreatic islets. …