TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. [5] It is encoded by the TBK1 gene in humans. [6] This kinase is …

Jul 10, 2020 · TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to …

Dec 25, 2024 · TBK1 (TANK Binding Kinase 1) is a Protein Coding gene. Diseases associated with TBK1 include Encephalopathy, Acute, Infection-Induced 8 and Frontotemporal Dementia …

Jan 12, 2023 · Using a suite of genetic and pharmacological tools across multiple experimental model systems, we confirm a role for TBK1 as an immune-evasion gene. Targeting TBK1 …

Mar 7, 2025 · TBK1 (TANK binding kinase 1) and IKKε [inhibitor of nuclear factor κ B (NF-K B) kinase subunit ε] are two central kinases in the regulation of several cellular processes and …

Abstract. TANK-binding kinase 1 (TBK1) is a key signaling kinase involved in innate immune and inflammatory responses. TBK1 drives immune cells to participate in the inflammatory response …

Aug 6, 2021 · Homozygous LoF TBK1 produces systemic autoinflammation, not overt viral disease. Expressed but inactive TBK1 inhibits IFN-I induction more than no TBK1. …

Mar 21, 2024 · TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation.

Oct 1, 2021 · In this review, we highlight the diverse biological functions of TBK1 and summarize the promising small-molecule inhibitors of TBK1 that have the potential to be developed as …

Jan 1, 2018 · Also known as NAK (NF-κB-activating kinase) or T2K (TRAF2-associated kinase), TBK1 is a ubiquitously expressed 729-amino-acid serine/threonine kinase that is a …