TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates in blood cell formation, forms mesoderm in early embryogenesis, and regulates hematopoiesis in adult organisms.

Dec 25, 2024 · TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Precursor T-Cell Acute Lymphoblastic Leukemia and Leukemia, Acute Lymphoblastic .

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene. [5] [6] The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

May 1, 2023 · T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur through diverse cis-alterations, including SIL-TAL1 microdeletions, translocations with T-cell Receptor loci, and more rec …

TAL1 modulates NFKB1 expression and an NF-kappaB-dependent transcriptional program in a subset of human T-cell leukemia cells. TAL1 may act as a bifunctional transcriptional regulator (activator and repressor) at the top of a complex regulatory network that disrupts normal T-cell homeostasis and contributes to leukemogenesis.

TAL1 is an essential regulator of hematopoiesis that plays crucial roles in the maintenance of hematopoietic stem cells (HSC) and progenitor cells as well as in the specification and maturation of erythro-megakaryocyte lineage. 1-3 During normal T-cell development, TAL1 and its binding partner LMO2 are silenced, which enables the formation of E ...

T-cell acute lymphoblastic leukemia (T-ALL) protein 1 (TAL1) is a central transcription factor in hematopoiesis. The timing and level of TAL1 expression orchestrate the differentiation to specialized blood cells and its overexpression is a common ...

TAL1, also known as SCL, is a transcription factor that plays a crucial role in early hematopoiesis. It is expressed in normal erythroid precursors and megakaryocytes, but not in normal T cells.

Oct 10, 2022 · The transcriptional regulator Tal1 exerts essential functions in the earliest stages of blood development, but is considered dispensable for the EHT.

In this review, we focus on the oncogenic transcription factor TAL1 and the tumor-suppressor E-proteins and discuss the malignant cell state, the transcriptional circuit, and the consequence of molecular abnormalities in T-ALL.