2024年12月25日 · TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and NOTCH2 Activation and Transmission of Signal to the Nucleus.

2025年1月24日 · TACC3 is the most oncogenic member of the transforming acidic coiled-coil domain-containing protein (TACC) family. It is one of the major recruitment factors of distinct multi-protein complexes. TACC3 is localized to spindles, centrosomes, and ...

含转化酸性卷曲螺旋 3： 该基因编码转化酸性大肠杆菌蛋白家族的成员。编码的蛋白质是一种运动纺锤体蛋白，可能在有丝分裂纺锤体的稳定中发挥作用。这种蛋白质也可能在某些癌细胞的生长和分化中发挥作用。[RefSeq 提供，2011 年 11 月]

2021年1月4日 · We demonstrated that inhibiting TACC3 not only blocks mitotic progression but also inhibits G1/S progression via disruption of the TACC3/KIFC1 complex in mitosis and the TACC3/HDAC2/MBD2...

Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene. [5] [6] The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic ...

2024年1月10日 · TACC3 is the most oncogenic member of the transforming acidic coiled-coil domain-containing protein (TACC) family. It is one of the major recruitment factors of distinct multi-protein complexes. TACC3 is localized to spindles, centrosomes, and nucleus, and regulates key oncogenic processes, includin …

2023年11月27日 · In this study, by exploiting the TCGA database, we found that high TACC3 expression in PDAC is associated with poor prognosis. shRNA-mediated TACC3 knockdown caused S phase arrest of the cell...

在这里，我们发现转化酸性卷曲螺旋蛋白 3 (tacc3) 在患有 ca 的肿瘤中过度表达，其高表达与显着更差的临床结果相关。 我们第一次展示了，TACC3 形成不同的功能性相互作用体，调节有丝分裂和间期的不同过程，以确保 CA 癌细胞的增殖和存活。

tacc3蛋白在乳腺癌组织中的表达水平明显高于 癌旁正常组织（P<0.05），并且TACC3蛋白表达在年龄、 是否绝经、ER、PR、Ki-67、HER-2方面差异无统计学意

在此，本研究确定转录相关酸性卷曲蛋白3（TACC3）是一种新的中心体扩增导向的产物，可通过在细胞周期进程中形成完全不同的功能产物来驱动高度侵袭性细胞的生长，并且首次证明，TACC3通过其在CA有丝分裂细胞中的TACC结构域与Kinesin家族成员C1（KIFC1）相互作用 ...