The protein encoded by the TAS1R1 gene is a G protein-coupled receptor with seven trans-membrane domains and is a component of the heterodimeric amino acid taste receptor T1R1+3.

2023年12月13日 · Here, we report five previously uncharacterized TAS1R members in vertebrates, TAS1R4, TAS1R5, TAS1R 6, TAS1R7 and TAS1R8, based on genome-wide survey of diverse taxa. We show that mammalian and...

2017年5月23日 · Here we present crystal structures of the extracellular ligand-binding domains (LBDs), the taste recognition regions of the fish T1r2-T1r3 heterodimer, bound to different amino acids. The...

2019年6月30日 · Here, using homology modeling, molecular docking and molecular dynamics (MD) simulations, we investigate the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3. Our work identifies the key residues that are directly involved in recognizing the binding ligands.

2012年9月28日 · We identify the G protein-coupled receptor (GPCR) T1R1/T1R3 as a direct sensor of the fed state and amino acid availability. Knocking down this receptor, which is found in most tissues, reduces the ability of amino acids to signal to mTORC1.

2002年2月24日 · Here we identify and characterize a mammalian amino-acid taste receptor. This receptor, T1R1+3, is a heteromer of the taste-specific T1R1 and T1R3 G-protein-coupled receptors.

2024年12月25日 · TAS1R1 (Taste 1 Receptor Member 1) is a Protein Coding gene. Diseases associated with TAS1R1 include Dental Caries and Polycystic Kidney Disease 1. Among its related pathways are GPCR downstream signalling and Sensory perception of taste.

There are three proteins in the family, T1R1, T1R2, and T1R3, encoded by their respective genes, Tas1r1, Tas1r2, and Tas1r3. T1R2 combines with T1R3 to form a heterodimer that binds with sugars and other sweeteners. T1R3 also combines with T1R1 to form a heterodimer that binds with L-amino acids.

In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 member 3 (T1R3) in a subset of hepatic NK cells in a mouse HCC model. T1R1 and T1R3 were selectively expressed in CD49a + CD49b-NK cells in livers with HCC.

Functional expression of T1Rs in human embryonic kidney (HEK)-293 cells revealed that different combinations of T1Rs respond to sweet and umami taste stimuli (6, 7). T1R2 and T1R3, when coexpressed in HEK-293 cells, recognize diverse natural and synthetic sweeteners.