The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal ...

2016年5月1日 · Translocation t(8;21) is found in 5-12% of AML. Among the non-random chromosomal aberrations observed in AML, t(8;21)(q22;q22) is one of the best known and usually correlates with AML M2, with well defined and specific morphological features.

2020年1月14日 · The t(8;21)(q22;q22.1) translocation is a leukemogenic alteration that leads to a novel chimeric gene RUNX1-RUNX1T1, generated on the derivative chromosome 8. This translocation generates a fusion gene, which consists of the RUNX1 gene from chromosome 21 and the RUNX1T1 gene from chromosome 8.

2013年11月15日 · Translocation t(8;21) with the resulting RUNX1-RUNX1T1 rearrangement is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Although it is generally associated with a favourable prognosis, many additional genetic lesions may …

2021年4月12日 · AML with t(8;21)(q22;q22.1) is caused by a recurrent genetic rearrangement that results in the fusion of RUNX1 and RUNX1T1 and predisposes to acute myeloid leukemia with generally favorable prognosis

The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. It has been shown that the t(8;21) breakpoints on chromosome 21 cluster within a single specific intron of the AML1 gene, which is highly homologous to the Drosophila segmentation gene runt.

The t(8;21)(q22;q22) translocation is a non-random chromosomal abnormality frequently found in patients with acute myeloid leukemia (AML) with maturation (M2 subtype). We report here the cloning of a gene, named AML1, on chromosome 21 that was found to be rearranged in the leukemic cell DNAs from t(8;21) AML patients.

This test is a highly sensitive quantitative assay for the detection of translocation t(8;21)(q22;q22); RUNX1-RUNX1T1 gene fusion in acute myeloid leukemia patients, at the time of diagnosis as well as minimal residual disease monitoring during …

2020年12月13日 · One of the best-studied AML-subtypes is the t(8;21) AML which carries a translocation fusing the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO gene. The resulting oncoprotein, RUNX1/ETO has been studied for decades, both at the biochemical but also at the systems biology level.

2017年1月1日 · The translocation t(8;21) is found in about 10% of adult acute myeloid leukemia (AML) patients. Patients with t(8;21) are generally younger than 60 years. Most cases of t(8;21)-positive AML show a FAB M2 or, less often, a M1 subtype, that is with (M2) or with minimal (M1) signs of maturation. This translocation marks a subgroup of patients ...